{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:52:55Z","timestamp":1763016775150},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T00:00:00Z","timestamp":1181001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle hemoglobin (Hb S; \u03b2 Glu6Val) is due to an A&gt;<jats:italic>T<\/jats:italic> transversion in codon 6 of the \u03b2\u2010globin gene. Other variant hemoglobins mimic Hb A, S, or C on newborn screening and clinical laboratory diagnostic tools, thus making their correct identification potentially difficult. Sickling disorders can result in individuals who are compound heterozygous for \u03b2\u2010globin mutations (e.g., Hb SC, HbSO<jats:sup>Arab<\/jats:sup>). The authors report a second case of HbS\/Qu\u00e9bec\u2010CHORI, a severe compound heterozygous sickling disorder and their experience managing this patient with hydroxyurea. Pediatr Blood Cancer 2007;49:207\u2013210. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21269","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T03:13:40Z","timestamp":1181099620000},"page":"207-210","source":"Crossref","is-referenced-by-count":6,"title":["Sickle cell disease caused by Hb S\/Qu\u00e9bec\u2010CHORI: Treatment with hydroxyurea and response"],"prefix":"10.1002","volume":"49","author":[{"given":"Ven\u00e9e N.","family":"Tubman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010yuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.K.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Heeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3628"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2475"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2704"},{"key":"e_1_2_5_5_2","first-page":"1550","article-title":"Safety of hydroxyurea in children with sickle cell anemia: Results of the HUG\u2010KIDS study, a phase I\/II trial. 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