{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:11:47Z","timestamp":1789009907224,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T00:00:00Z","timestamp":1181088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum ferritin (SF) and liver iron concentration (LIC), as measured by SQUID biosusceptometry, were assessed in a convenience sample of transfusion independent thalassemia patients (nTx\u2010Thal, n\u2009=\u200926), regularly transfused thalassemia (Tx\u2010Thal, n\u2009=\u200989), or sickle cell patients (SCD, n\u2009=\u200945) to investigate the severity of iron overload and the relationship between SF and LIC in nTx\u2010Thal compared to SCD and Tx\u2010Thal. SF correlated with LIC (R<jats:sub>S<\/jats:sub>\u2009=\u20090.53, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but was found to be a poor predictor for LIC. SF was significantly lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in nTx\u2010Thal patients than in other groups, despite similar LIC values. The SF\u2010to\u2010LIC ratio was significantly lower in nTx\u2010Thal compared to Tx\u2010Thal and SCD patients (median of 0.32, 0.87, and 1.2, respectively: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Due to underestimation of LIC by ferritin levels, chelation treatment may be delayed or misdirected in patients with thalassemia intermedia. Pediatr Blood Cancer 2007;49:329\u2013332. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21275","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T21:47:53Z","timestamp":1181166473000},"page":"329-332","source":"Crossref","is-referenced-by-count":98,"title":["Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients"],"prefix":"10.1002","volume":"49","author":[{"given":"Zahra","family":"Pakbaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Harmatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Vichinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90276-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1982.tb00510.x"},{"key":"e_1_2_6_4_2","first-page":"657","article-title":"Plasma ferritin determination as a diagnostic tool","volume":"145","author":"Finch CA","year":"1986","journal-title":"West J Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830420116"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02298.x"},{"key":"e_1_2_6_7_2","first-page":"286","volume-title":"Magnetism in medicine\u2014A handbook","author":"Fischer R","year":"1998"},{"key":"e_1_2_6_8_2","first-page":"5","article-title":"The New SQUID Biosusceptometer at Oakland: First year of experience","author":"Fung E","year":"2004","journal-title":"Neurol Clin Neurophysiol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212303072703"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.739"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013482"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199904)60:4<289::AID-AJH7>3.0.CO;2-W"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(00)00101-6"},{"key":"e_1_2_6_14_2","first-page":"397","volume-title":"Hematology: Basic principals and practice","author":"Brittenham GM","year":"2000"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04734.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4844"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"e_1_2_6_18_2","first-page":"276","article-title":"Geomagnetic reversals driven by sudden climate changes","volume":"70","author":"Muller RA","year":"1989","journal-title":"Eos"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1029\/GL015i008p00768"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1984.tb00681.x"},{"key":"e_1_2_6_21_2","first-page":"89","article-title":"Iron metabolism in thalassemia intermedia","volume":"75","author":"Fiorelli G","year":"1990","journal-title":"Haematologica"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T01:03:00Z","timestamp":1697677380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/pbc.21275"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21275","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,6]]}}}