{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:21:37Z","timestamp":1758820897029},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T00:00:00Z","timestamp":1181088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the effects of chemotherapy on patient antibody titers to vaccine\u2010preventable infectious diseases; thus, there is no standard protocol for revaccinating post\u2010chemotherapy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>To assess losses of detectable antibody titers due to chemotherapy, we retrospectively examined antibody titers for tetanus, varicella, measles, mumps, rubella, hepatitis B, and polio in 109 pediatric sarcoma patients. We also evaluated revaccination data to determine current practices and efficacy of revaccination. We limited our sample to osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma patients to control for the chemotherapy regimen patients received.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had pre\u2010treatment detectable antibody titer that fell within the range of healthy children's antibody titers. However, 71% of patients had post\u2010chemotherapy negative titers for at least one infectious disease. Patients most commonly had negative titers for hepatitis B (64%). Few patients had negative titers for measles (14%), mumps (9%), rubella (4%), polio 1 (0%), polio 2 (2.9%), polio 3 (4.8%), tetanus (5%), or varicella (11%). Revaccinations most frequently administered were hepatitis B and polio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that post\u2010chemotherapy patients may need to be revaccinated against certain vaccine\u2010preventable diseases including hepatitis B, tetanus, varicella, polio, measles, mumps, and rubella. Larger studies need to be performed to establish guidelines for revaccinating post\u2010chemotherapy pediatric patients. Pediatr Blood Cancer 2007;49:656\u2013660. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21277","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T21:48:06Z","timestamp":1181166486000},"page":"656-660","source":"Crossref","is-referenced-by-count":21,"title":["Loss of antibody titers and effectiveness of revaccination in post\u2010chemotherapy pediatric sarcoma patients"],"prefix":"10.1002","volume":"49","author":[{"given":"Jennifer","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Lennox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Kleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard H.","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Gorlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,6]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"455","article-title":"Immunisations after bone marrow transplantation: Results of a European survey and recommendations from the infectious diseases working party of the European Group for Blood and Marrow Transplantation","volume":"15","author":"Ljungman P","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10152"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00340.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20384"},{"key":"e_1_2_5_6_2","first-page":"641","article-title":"Phytohemagglutinin skin test: Diagnostic value for showing immunodeficiency in patients with cancer","volume":"66","author":"Sone S","year":"1975","journal-title":"Gann"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.033"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020890"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1481::AID-CNCR2820690628>3.0.CO;2-L"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-1-10"},{"key":"e_1_2_5_11_2","first-page":"243","article-title":"Impact of vaccines universally recommended for children\u2013United States, 1990\u20131998","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:29:3:167"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.e91"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017922302854"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.13.1481"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-5-200503010-00008"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200101000-00013"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00384-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","unstructured":"BellierB Thomas\u2010VaslinV SaronMF et al.Turning immunological memory into amnesia by depletion of dividing T cells. 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