{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:00:27Z","timestamp":1780102827385,"version":"3.54.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorder (PTLD) in the central nervous system (CNS) has a poor prognosis. New therapeutic approaches should be explored. We report our experience with intrathecal administration of rituximab in a 10\u2010year\u2010old kidney allograft recipient with PTLD in the CNS. After standard treatment had failed, we tried to <jats:italic>treat<\/jats:italic> the patient by administering rituximab directly into the cerebral ventricle through an Omaya reservoir, in addition to conventional intrathecal and systemic chemotherapy. This strategy resulted in a disappearance of clinical symptoms and a negative positron emission tomogram. Intrathecal administration of rituximab may be a feasible approach in children with PTLD in the CNS. However, its specific role in our patient remains uncertain. Pediatr Blood Cancer 2008;50:886\u2013888. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21297","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T22:48:11Z","timestamp":1186008491000},"page":"886-888","source":"Crossref","is-referenced-by-count":45,"title":["Intrathecal rituximab treatment for pediatric post\u2010transplant lymphoproliferative disorder of the central nervous system"],"prefix":"10.1002","volume":"50","author":[{"given":"Gretha","family":"van de Glind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siebold","family":"de Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Maecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Loeffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1392-x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00519.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56352-2_10"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.03.015"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200507010-00005"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109099335"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00401.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1636"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.130"},{"key":"e_1_2_4_11_2","unstructured":"MaeckerB JackT ZimmermannM et al. Posttransplant lymphoproliferative disorders (PTLD) after solid organ transplantation in children: A multicenter analysis reveals CNS and\/or bone marrow involvement as risk factors for poor survival(submitted for publication)."},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00284.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0377"},{"key":"e_1_2_4_14_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1182\/blood.V104.11.746.746","article-title":"Anti\u2010CD20 monoclonal antibody (rituximab) for refractory PTLD after pediatric solid organ transplantation: Multicenter experience from a registry and from a prospective clinical trial","volume":"104","author":"Webber S","year":"2004","journal-title":"Blood"},{"key":"e_1_2_4_15_2","first-page":"753","article-title":"Intraventricular treatment of relapsed central nervous system lymphoma with the anti\u2010CD20 antibody rituximab","volume":"88","author":"Schulz H","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-006-9217-y"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199208000-00011"},{"key":"e_1_2_4_18_2","first-page":"106","article-title":"Posttransplant lymphoproliferative disorders in pediatric solid organ recipients: A multicenter retrospective analysis of patients from 1990 to 2003","author":"Maecker B","year":"2005","journal-title":"Blood"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21297","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:54:45Z","timestamp":1697082885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/pbc.21297"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21297","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}