{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:07:58Z","timestamp":1775761678421,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T00:00:00Z","timestamp":1189641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"T32 NRSA Training Grant","award":["CA009640"],"award-info":[{"award-number":["CA009640"]}]},{"name":"The Southwestern Clinical Research Scholars Program","award":["K12 RR02351"],"award-info":[{"award-number":["K12 RR02351"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent data suggest that adults with hereditary spherocytosis (HS) may be protected from atherothrombosis before splenectomy but have increased risk of thrombosis following splenectomy. In order to aid in making informed decisions regarding splenectomy in children with HS, we conducted a retrospective study of several surrogate laboratory markers of thrombosis risk in children with HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective record review was performed on 246 children with HS. Platelet count and hemoglobin concentration were recorded prior to and following splenectomy in each patient. Serum cholesterol levels were collected from the record when available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to splenectomy, hypocholesterolemia was common. Mean platelet counts in 31 evaluable patients pre\u2010 and post\u2010splenectomy were 334 and 608\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Twenty\u2010nine patients (94%) exhibited persistent thrombocytosis following splenectomy. Hemoglobin values following splenectomy often rose to higher than age and gender\u2010matched norms, with 30% of measurements greater than the 90th percentile and 17% greater than the 97th percentile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of hypocholesterolemia before splenectomy and thrombocytosis and mild polycythemia afterwards support the hypothesis that patients with HS might be protected from thrombosis before splenectomy and\/or more susceptible afterwards. Prospective studies of additional prothrombotic biomarkers and thrombotic events in HS patients are warranted. Pediatr Blood Cancer 2007;49:781\u2013785. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21319","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T20:16:34Z","timestamp":1189714594000},"page":"781-785","source":"Crossref","is-referenced-by-count":29,"title":["Laboratory markers of thrombosis risk in children with hereditary spherocytosis"],"prefix":"10.1002","volume":"49","author":[{"given":"Sarah B.","family":"Troendle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Adix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley E.","family":"Crary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64276-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00014"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760528"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90132-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005481114220"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0903.2004.00580.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199801)57:1<82::AID-AJH15>3.0.CO;2-B"},{"key":"e_1_2_6_9_2","first-page":"381","article-title":"Hereditary spherocytosis and portal vein thrombosis","volume":"6","author":"McGrew W","year":"1984","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20566"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80344-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1998.0376"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331978803900602"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800821230"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034587"},{"key":"e_1_2_6_16_2","first-page":"264","article-title":"Blood coagulation and platelet profiles in persistent post\u2010splenectomy thrombocytosis. 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