{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:13:29Z","timestamp":1790878409248,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T00:00:00Z","timestamp":1193788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radioiodinated metaiodobenzylguanidine [<jats:sup>131<\/jats:sup>I\u2010MIBG] is commonly used to treat resistant neuroblastoma or metastatic pheochromocytoma [MP] with little non\u2010hematopoietic toxicity. We describe here transient sialoadenitis, a previously unreported complication. Ten patients [9 neuroblastoma and 1 MP] received 12\u201318 mCi\/kg of <jats:sup>131<\/jats:sup>I\u2010MIBG. Five patients had bilateral parotid swelling, two with associated buccal discomfort within 24 hr of injection which subsided within 48 hr. Grade 3 or 4 serum amylase elevation was documented in 8\/8 patients tested [median 1,336; range: 576\u20138,830 U\/L] which normalized [25\u2013125 U\/L] within 4\u201314 [median 5.5] days. Serum lipase remained normal. Patients did not develop subsequent dry mouth or dysphagia. Pediatr Blood Cancer 2008;50:1271\u20131273. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21391","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T22:16:57Z","timestamp":1193869017000},"page":"1271-1273","source":"Crossref","is-referenced-by-count":37,"title":["Transient sialoadenitis: A complication of <sup>131<\/sup>I\u2010metaiodobenzylguanidine therapy"],"prefix":"10.1002","volume":"50","author":[{"given":"Shakeel","family":"Modak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Pandit\u2010Taskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smith\u2010Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Kong V.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.3484"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20240"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1353.050"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11167"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.058"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6694223"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.229"},{"key":"e_1_2_6_9_2","first-page":"1551","article-title":"long\u2010term side effects of high\u2010dose radioiodine therapy for thyroid carcinoma","volume":"39","author":"Alexander C","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2006.11.005"},{"key":"e_1_2_6_11_2","first-page":"2","article-title":"Salivary gland accumulation of meta\u2010[131I]iodobenzylguanidine","volume":"25","author":"Nakajo M","year":"1984","journal-title":"J Nucl Med"},{"key":"e_1_2_6_12_2","first-page":"1","article-title":"Radiolabeled meta\u2010iodobenzylguanidine and the adrenergic neurons of salivary glands","volume":"2","author":"Sisson JC","year":"1987","journal-title":"Am J Physiol Imaging"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199502000-00011"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/clinchem\/32.4.609","article-title":"Salivary amylase and pancreatic enzymes in serum after total body irradiation","volume":"32","author":"Junglee D","year":"1986","journal-title":"Clin Chem"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321582060"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.1083"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196105112641908"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198705000-00009"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199610000-00006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-59-697-45"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:39:29Z","timestamp":1697629169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,31]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/pbc.21391"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21391","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,31]]}}}