{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:54Z","timestamp":1740138594349,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by intra\u2010alveolar accumulation of periodic acid\u2010Schiff (PAS)\u2010positive surfactant components. Leukemia is the cancer most often associated with PAP; prolonged neutropenia and reduction of alveolar macrophages by myeloablative chemotherapy or leukemic infiltration are implicated. Only isolated cases of PAP have been reported, and pediatric experience is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We reviewed all pathology records (1962\u20132007) of St. Jude Children's Research Hospital to identify patients with PAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients had PAP. As expected, all had leukemia and had profound neutropenia at onset of PAP. A diagnosis was made only after PAS staining of bronchoalveolar lavage (BAL), lung biopsy, or autopsy specimens. Two patients had Down syndrome, which is not known to be associated with PAP. The other three patients had undergone hematopoietic stem cell transplantation (HSCT). Two patients showed clinical improvement or histological disappearance of PAP after neutropenia resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PAP should be considered in the differential diagnosis of severe respiratory symptoms in neutropenic patients with hematologic malignancy, especially those with Down syndrome, a history of HSCT, or active disease. PAP should be confirmed by PAS staining of a BAL or lung biopsy specimen. Pediatr Blood Cancer 2008;51:66\u201370. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21442","type":"journal-article","created":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T22:46:41Z","timestamp":1197931601000},"page":"66-70","source":"Crossref","is-referenced-by-count":15,"title":["Pulmonary alveolar proteinosis in pediatric leukemia"],"prefix":"10.1002","volume":"51","author":[{"given":"Hiroto","family":"Inaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse J.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Beth","family":"McCarville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Ray","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-2-153"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1385"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023226"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.1.r99ap10155"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119758"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280606"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102223440805"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.6.875"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1565"},{"key":"e_1_2_5_11_2","first-page":"1097","article-title":"Defective expression of granulocyte\u2010macrophage colony\u2010stimulating factor\/interleukin\u20103\/interleukin\u20105 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure","volume":"92","author":"Dirksen U","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.8118651"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/122.2.303"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.1.277"},{"key":"e_1_2_5_15_2","first-page":"527","article-title":"Alveolar proteinosis as a consequence of immunosuppression. A hypothesis based on clinical and pathologic observations","volume":"11","author":"Bedrossian CW","year":"1980","journal-title":"Hum Pathol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403872"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.775638"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00218-7"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171324"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029363"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05591.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00178-3"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211043071902"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90183-P"},{"key":"e_1_2_5_25_2","first-page":"608","article-title":"Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891","volume":"91","author":"Lange BJ","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20092"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2337"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/378776a0"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.227"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000055093"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:12:25Z","timestamp":1696853545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,19]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/pbc.21442"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21442","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2007,12,19]]}}}