{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:50:59Z","timestamp":1767840659188,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T00:00:00Z","timestamp":1201737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical impact of influenza in children undergoing therapy for cancer is not well\u2010described in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Laboratory\u2010documented influenza infection in pediatric oncology patients cared for in a single regional pediatric medical center between July 2000 and June 2005 was identified by review of medical and laboratory records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven clinical encounters were identified in 24 pediatric oncology patients with influenza infection. Eighty\u2010three percent of patients were receiving chemotherapy for hematologic or solid malignancies. Two\u2010thirds of patients were hospitalized for a median duration of 7.4 days; 40% of patients experienced a delay in scheduled chemotherapy as result of influenza infection. Most children (67%) were not neutropenic, although 63% were lymphopenic. Importantly, 15% of children with influenza had simultaneously diagnosed bacteremia. Concomitant pathogens included <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Enterobacter cloacae<\/jats:italic>, <jats:italic>Enterococcus faecalis<\/jats:italic>, and coagulase\u2010negative <jats:italic>Staphylococcus<\/jats:italic>. Primary influenza pneumonia and\/or respiratory failure occurred in three children, and ventilatory support was required in four clinical encounters. Antiviral medications were administered to 63% of patients within 2 days of influenza diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pediatric oncology patients experienced significant influenza\u2010associated morbidities. Influenza infection should be considered in febrile children with respiratory symptoms during the respiratory viral season, as well as concurrent bacterial or fungal infections. Pediatr Blood Cancer 2008;50:983\u2013987. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21472","type":"journal-article","created":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T18:47:26Z","timestamp":1201805246000},"page":"983-987","source":"Crossref","is-referenced-by-count":55,"title":["Influenza\u2010associated morbidity in children with cancer"],"prefix":"10.1002","volume":"50","author":[{"given":"Sarah K.","family":"Tasian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie R.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Englund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10208"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10130"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80325-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20469"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/322628"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.2.394"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.1.166"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200204000-00007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197701)39:1<350::AID-CNCR2820390153>3.0.CO;2-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199508000-00008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000210061.96075.8e"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00216-06"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)80004-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.5.778"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/513648"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/425004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16934-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/314440"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/500465"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/516358"},{"key":"e_1_2_6_23_2","first-page":"401","volume-title":"Red Book: Report of the Committee on Infectious Disease","author":"American Academy of Pediatrics","year":"2006"},{"key":"e_1_2_6_24_2","first-page":"1","article-title":"Prevention and control of influenza: Recommendations of the advisory committee on immunization practices","volume":"55","author":"Centers for Disease Control and Prevention","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200302000-00010"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.006"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.6.496"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39105.428981.BE"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T16:07:06Z","timestamp":1695917226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,31]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/pbc.21472"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21472","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,31]]}}}