{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:02:28Z","timestamp":1698714148812},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T00:00:00Z","timestamp":1203552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim was to evaluate the role of leukocyte transfusions (LTX) in relation to graft function during prolonged neutropenia after stem cell transplantation (SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>In 1989\u20132005, 22 SCT patients have received LTX in our unit. In all patients severe infection with profound neutropenia (&lt;0.2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) preceded LTX. 13\/22 had multi\u2010organ failure or thrombotic microangiopathy. Irradiated leukocytes from pooled random donor products at 1.0\u2009\u00d7\u200910<jats:sup>10<\/jats:sup> leukocytes\/m<jats:sup>2<\/jats:sup>\/day for a minimum of 3 days were used. Myeloid recovery and clinical benefit were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Engraftment defined as an absolute neutrophil count (ANC) of &gt;0.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L on three consecutive days was observed in 15\/22 (68%) patients at median of 6 (range 2\u201325) days after LTX, and sustained engraftment (ANC of &gt;0.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L for 4 weeks) in 11\/22 (50%) patients. Clinical benefit was observed in 6\/22 (27%) patients with a prolonged antecedent neutropenia, who still demonstrated rapid sustained engraftment after LTX. Ongoing thrombotic microangiopathy was associated with persistent graft failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LTX from random donors was associated with a rapid recovery of myeloid function in severely ill SCT patients. We speculate that allostimulation by LTX may have a role. Pediatr Blood Cancer 2008;50:1247\u20131252. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21526","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T20:21:27Z","timestamp":1203625287000},"page":"1247-1252","source":"Crossref","is-referenced-by-count":3,"title":["Leukocyte transfusions revisited: Stem cell graft stimulation in graft failure"],"prefix":"10.1002","volume":"50","author":[{"given":"Mervi","family":"Taskinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimmo","family":"Talvensaari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Hovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Vettenranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla M.","family":"Saarinen\u2010Pihkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"844","article-title":"Replacement therapy using normal and chronic myelogenous leukaemia leukocytes","volume":"24","author":"Yankee RA","year":"1964","journal-title":"Blood"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/blood.V33.2.353.353","article-title":"Leukapheresis by continuous flow centrifugation in patients with chronic myelocytic leukaemia","volume":"33","author":"Buckner D","year":"1969","journal-title":"Blood"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90200-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-509"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704630"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20337"},{"key":"e_1_2_6_8_2","first-page":"649","article-title":"Incidence and clinical features of cytomegalovirus infection diagnosed by cytomegalovirus pp65 antigenemia assay during high dose corticosteroid therapy for collagen vascular diseases","volume":"24","author":"Yamashita M","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703922"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb02559.x"},{"key":"e_1_2_6_11_2","first-page":"126","article-title":"Transplantation\u2010associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome","volume":"34","author":"Schriber JR","year":"1997","journal-title":"Semin Hematol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05221.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.9.3222"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401699"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(03)00067-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2717"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.1.333.413a31_333_339"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.03.008"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200607152-03014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39101136.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1966.tb04723.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20710"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000190114.38650.b2"}],"container-title":["Pediatric Blood &amp; 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