{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:39:09Z","timestamp":1760852349867},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T00:00:00Z","timestamp":1203552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia (AML). Treatment of pediatric APL is based on the combination of all\u2010<jats:italic>trans<\/jats:italic>\u2010retinoic acid (ATRA), an anthracycline and cytosine arabinoside. Arsenic trioxide (ATO) has been studied in adults with newly diagnosed or relapsed APL with excellent response rates both when used as a single agent or in combination with ATRA or ATRA plus chemotherapy. There is little data on combination therapy with ATRA and ATO in pediatric APL. We present a case of an adolescent male with APL who was treated using ATRA and ATO without conventional chemotherapy agents. Pediatr Blood Cancer 2008;51:133\u2013135. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21529","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T20:21:53Z","timestamp":1203625313000},"page":"133-135","source":"Crossref","is-referenced-by-count":14,"title":["All\u2010<i>trans<\/i>\u2010retinoic acid and arsenic trioxide as initial therapy for acute promyelocytic leukemia"],"prefix":"10.1002","volume":"51","author":[{"given":"Gerardo","family":"Quezada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elihu","family":"Estey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,21]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391901"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.008"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.3359"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1971"},{"key":"e_1_2_4_6_2","first-page":"1231","article-title":"Arsenic trioxide in the treatment of acute promyelocytic leukemia. A review of the current evidence","volume":"90","author":"Sanz MA","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402106"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.18.3852"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22524"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400053101"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4006"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3532"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20492"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.04.019"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2462"},{"key":"e_1_2_4_17_2","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1182\/blood.V93.12.4131","article-title":"Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all\u2010trans\u2010retinoic acid: Results of a randomized MRC trial","volume":"93","author":"Burnett AK","year":"1999","journal-title":"Blood"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21529","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:14:36Z","timestamp":1696853676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,21]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/pbc.21529"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21529","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,21]]}}}