{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:54:12Z","timestamp":1788872052220,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T00:00:00Z","timestamp":1203897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"COG","award":["98543"],"award-info":[{"award-number":["98543"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral T\u2010cell lymphomas (PTCL) other than anaplastic large cell lymphoma (ALCL) are rare in young patients. While a high proportion of adults with PTCL have poor risk disease, pediatric PTCL is not well characterized. This study examines the outcome of localized and advanced PTCL in pediatric patients treated in standardized fashion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>We identified 20 pediatric patients diagnosed with PTCL whose tumor cells did not express CD30 and\/or ALK, as determined by immunohistochemistry, between 1992 and 2000 on one of two treatment protocols for localized NHL (POG 9219) or advanced stage large cell lymphoma (POG 9315). All cases were centrally reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 12.6 (range 0.7\u201316.9)\u20149 male and 11 female. Histological subtypes in the WHO Classification included PTCL, unspecified (12), extra\u2010nodal NK\/T\u2010cell lymphoma of nasal type (4), subcutaneous panniculitis\u2010like T cell lymphoma (1) and enteropathy\u2010type T\u2010cell lymphoma (1). Two cases exhibited both T\u2010cell and histiocyte markers and were reclassified as histiocytic sarcoma per the WHO, although T\u2010lineage remains possible. Of 10 patients with localized disease, only two relapsed and 9 survive. Of 10 patients with advanced disease, six relapsed and five (50%) survive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that localized PTCL in children and adolescents is frequently cured with modern therapy, but that advanced stage cases may require novel therapy. Pediatr Blood Cancer 2008;51:29\u201333. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.21543","type":"journal-article","created":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T17:58:25Z","timestamp":1203962305000},"page":"29-33","source":"Crossref","is-referenced-by-count":61,"title":["Non\u2010anaplastic peripheral t\u2010cell lymphoma in childhood and adolescence: A Children's Oncology Group study"],"prefix":"10.1002","volume":"51","author":[{"given":"Robert E.","family":"Hutchison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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