{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:41:12Z","timestamp":1761716472432},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T00:00:00Z","timestamp":1208390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all\u2010trans\u2010retinoic acid. One patient developed FG. These lesions are predominantly seen in Asian population. A good outcome with supportive management occurred in all the cases. Pediatr Blood Cancer 2008;51:303\u2013304. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21549","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T17:49:14Z","timestamp":1208454554000},"page":"303-304","source":"Crossref","is-referenced-by-count":12,"title":["Fournier's gangrene and scrotal ulcerations during all\u2010trans\u2010retinoic acid therapy for acute promyelocytic leukemia"],"prefix":"10.1002","volume":"51","author":[{"given":"Rahul","family":"Naithani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mahapatra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,17]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.44.480"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106354"},{"key":"e_1_2_4_4_2","first-page":"55","article-title":"Scrotal ulcer occurring in patients with acute promyelocytic leukemia during treatment with all\u2010trans retinoic acid","volume":"6","author":"Mori A","year":"1999","journal-title":"Oncol Rep"},{"key":"e_1_2_4_5_2","first-page":"1169","article-title":"Acute promyelocytic leukemia accompanied by scrotal Fournier's Gangrene during ATRA treatment and relapsed as external ear tumor","volume":"39","author":"Goto H","year":"1998","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_4_6_2","first-page":"231","article-title":"Scrotal ulceration as a consequence of all\u2010trans\u2010retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia","volume":"4","author":"Simzar S","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-006-0230-1"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880010590964138"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.100"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02008.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20695"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.332678.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.1016\/S0021-9258(18)68323-1","article-title":"Transcriptional regulation of the leukocyte adherence protein beta subunit during human myeloid cell differentiation","volume":"268","author":"Hickstein DD","year":"1988","journal-title":"J Biol Chem"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T15:23:46Z","timestamp":1699975426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,17]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/pbc.21549"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21549","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,17]]}}}