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Current recommendations for trimethoprim\u2010sulfamethoxazole (TMP\u2010SMZ) dosing as PCP prophylaxis in immunocompromised patients are based on either daily dosing or dosing three consecutive days per week. We report our experience of prophylaxis with TMP\u2010SMZ twice daily on two non\u2010consecutive days per week in 145 immunocompromised children with hematologic disorders, cancer, or metabolic disorders following chemotherapy or hematopoietic stem cell transplantation. There were no breakthrough cases of PCP. We therefore conclude our prophylaxis regimen is effective against PCP in immunocompromised children. Pediatr Blood Cancer 2009;52:142\u2013144. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21774","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T18:01:36Z","timestamp":1222365696000},"page":"142-144","source":"Crossref","is-referenced-by-count":19,"title":["Intermittent oral trimethoprim\/sulfamethoxazole on two non\u2010consecutive days per week is effective as <i>Pneumocystis jiroveci<\/i> pneumonia prophylaxis in pediatric patients receiving chemotherapy or hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"52","author":[{"given":"Yasuhisa","family":"Ohata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Hashii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Tokimasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130130027008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712292972602"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.2.237"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80028-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198423000-00007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032588"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"1995 Revised Guidelines for Prophylaxis against Pneumocystis carinii Pneumonia for Children Infected with or Perinatally Exposed to Human Immunodeficiency Virus. 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