{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:16:01Z","timestamp":1790255761699,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T00:00:00Z","timestamp":1222300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although it is accepted that pediatric cancer treatment harbors a risk of gonadal damage, large cohort studies using up\u2010to\u2010date fertility markers are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The aim of our study was to evaluate the gonadal toxicity of childhood cancer treatment using fertility markers. We included 248 adult male long\u2010term survivors of childhood cancer. Median age at diagnosis: 5 years, median age at follow\u2010up: 24 years, median follow\u2010up time 18 years. We evaluated patient characteristics, treatment modalities, testicular size, and endocrinological parameters including Inhibin B, luteinizing hormone (LH), follicle\u2010stimulating hormone (FSH), and testosterone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median value of Inhibin B in the cancer survivor group was 126 ng\/L versus 177 ng\/L in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the survivors, 67% had Inhibin B levels below the normal reference value of 150 ng\/L compared with 26% in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Inhibin B was the most sensitive discriminator between survivors and controls. Significantly decreased Inhibin B levels and increased FSH levels were found in men treated for Hodgkin and non\u2010Hodgkin lymphoma, acute\u2010myeloid leukemia, neuroblastoma, and sarcoma as compared to other malignancies. Cumulative dosages of procarbazine and cyclophosphamide were the only independent chemotherapy\u2010related predictors for decrease of Inhibin B levels and increase of FSH. Age at time of treatment did not influence post\u2010treatment Inhibin B or FSH levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe gonadal impairment is a risk in a considerable subgroup of childhood cancer survivors based on current fertility markers like Inhibin B. Males receiving gonadotoxic treatment before puberty are not protected from post treatment gonadal dysfunction. Pediatr Blood Cancer 2009;52:108\u2013112. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21780","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T18:01:33Z","timestamp":1222365693000},"page":"108-112","source":"Crossref","is-referenced-by-count":128,"title":["Effect of childhood cancer treatment on fertility markers in adult male long\u2010term survivors"],"prefix":"10.1002","volume":"52","author":[{"given":"Niels J.","family":"van Casteren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert H.M.","family":"van der Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike 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