{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:10:05Z","timestamp":1758125405548},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with primary immunodeficiency or chromosomal breakage syndromes are at increased risk of developing non\u2010Hodgkin lymphomas; they cannot tolerate standard chemotherapy regimens. We report two children with diffuse, large, B\u2010cell lymphoma; one had ataxia telangiectasia and one had common variable immunodeficiency. Both were given rituximab, 1 as monotherapy and 1 in combination with a reduced CHOP regimen. Complete remission was obtained in each patient. Use of rituximab as a first\u2010line monotherapy or in conjunction with reduced chemotherapy should be considered to reduce cytotoxic effects. Pediatr Blood Cancer 2009;52:664\u2013666. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21808","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T17:33:51Z","timestamp":1231868031000},"page":"664-666","source":"Crossref","is-referenced-by-count":22,"title":["Rituximab as monotherapy and in addition to reduced CHOP in children with primary immunodeficiency and non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"52","author":[{"given":"Shimrit","family":"Shabbat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Aharoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Sarid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Ben\u2010Harush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kapelushnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61199-X"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328302c7b6"},{"issue":"1","key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/annonc\/11.suppl_1.S141","article-title":"Non\u2010Hodgkin's lymphoma in pediatric patients with chromosomal breakage syndromes (AT and NBS): Experience from the BFM trials","volume":"11","author":"Seidemann K","year":"2000","journal-title":"Ann Oncol"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.5.400"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.31.1.635"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036673"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036665"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06988.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363080-00005"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2005.05.007"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f424b0"},{"key":"e_1_2_4_15_2","first-page":"573","article-title":"The incidence and gene frequency of ataxia\u2010telangiectasia in the United States","volume":"39","author":"Swift M","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199912)33:6<536::AID-MPO3>3.0.CO;2-Z"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20548"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04041_4.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2007.n.046"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10050"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556130408300516"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:22:14Z","timestamp":1697653334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,13]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1002\/pbc.21808"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21808","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,13]]}}}