{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:02:53Z","timestamp":1776520973375,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T00:00:00Z","timestamp":1225929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain abscesses in children with leukemia or other malignancies are rare and potentially fatal. We report on four children who developed brain abscesses during treatment for acute lymphoblastic leukemia (ALL). All patients received multimodal broad\u2010spectrum antibiotic therapy and liposomal amphotericin\u2010B in combination with hyperbaric oxygen. First\u2010line antimicrobial treatment was modified when a causative organism was isolated. All four patients survived, with two patients showing complete resolution of neurological and MRI abnormalities and with two patients still having residual lesions. To date, all patients are in remission with three patients still receiving antileukemic therapy. Brain abscesses can be successfully managed by a multimodality approach even in severely immunocompromised cancer patients. Pediatr Blood Cancer 2009;52:408\u2013411. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21814","type":"journal-article","created":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T16:19:20Z","timestamp":1225988360000},"page":"408-411","source":"Crossref","is-referenced-by-count":10,"title":["Management of brain abscesses in children treated for acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"52","author":[{"given":"Herwig","family":"Lackner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Sovinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Benesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freyja","family":"Smolle\u2010J\u00fcttner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mokry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schwinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Moser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199504000-00032"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019809016579"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709068287"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.5.775"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.40.654"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.44.772"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01023.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00737.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.12.4569-4576.2000"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199807)31:1<19::AID-MPO4>3.0.CO;2-2"},{"key":"e_1_2_4_12_2","first-page":"991","article-title":"Fungal brain abscesses in leukemia","volume":"43","author":"Athanassiadou F","year":"2006","journal-title":"Indian Pediatr"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441214"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001628185"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880010050120863"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01755.x"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-005-1147-z"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000163215.37147.13"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.695-701.2002"},{"key":"e_1_2_4_20_2","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1128\/JCM.38.10.3892-3895.2000","article-title":"Granulomatous amebic encephalitis in a patient with AIDS: Isolation of acanthamoeba sp. group II from brain tissue and successful treatment with sulfadiazine and fluconazole","volume":"38","author":"Seijo Martinez M","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0235"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90380-V"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880010500278665"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T01:03:33Z","timestamp":1695949413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,8]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/pbc.21814"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21814","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,8]]}}}