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Computerized tomography on day 7 demonstrated appendicitis and multiple hepatic foci identified as mucormycosis (<jats:italic>Absidia corymbifera<\/jats:italic>). Successful outcome was achieved by aggressive re\u2010surgery, long\u2010term antifungal therapy with serum level\u2010monitored posaconazole, and recovery of neutrophil counts. Considering the interference of posaconazole with CYP3A4, vincristine was administered during 72 hr posaconazole windows. Pediatric intestinal mucormycosis, still associated with a &gt;70% case\u2010fatality rate, calls for early imaging and surgery to establish the diagnosis, reduce the fungal mass, and provide a rationale for using posaconazole. Pediatr Blood Cancer 2009;52:872\u2013874. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21918","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T15:44:40Z","timestamp":1239119080000},"page":"872-874","source":"Crossref","is-referenced-by-count":21,"title":["Treatment of intestinal and hepatic mucormycosis in an immunocompromized child"],"prefix":"10.1002","volume":"52","author":[{"given":"Sonja","family":"L\u00fcer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Diepold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Duppenthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"von Gunten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"M\u00fchlethaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Aebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318062115c"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.340-349.2006"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318030d289"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199310000-00013"},{"key":"e_1_2_5_6_2","first-page":"131","article-title":"Gastrointestinal mucormycosis\u2014an uncommon isolated mucormycosis","volume":"17","author":"Sharma MC","year":"1998","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90815-X"},{"key":"e_1_2_5_8_2","first-page":"1","article-title":"Successful therapy with ABLC, surgery and posaconazole for Rhizopus microsporus var. rhizopodiformis liver eumycetoma in a child with acute leukaemia","volume":"51","author":"Sedlacek P","year":"2008","journal-title":"Mycoses"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02760587"},{"key":"e_1_2_5_10_2","first-page":"430","article-title":"Antemortem diagnosis of gastrointestinal mucormycosis in neonates: Report of two cases and review of literature","volume":"49","author":"Agarwal K","year":"2006","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_5_11_2","first-page":"198","article-title":"Gastrointestinal mucormycosis in a neonate: Survival without antifungal therapy","volume":"26","author":"Budhiraja S","year":"2007","journal-title":"Indian J Gastroenterol"},{"key":"e_1_2_5_12_2","first-page":"81","article-title":"Neonatal gastrointestinal mucormycosis\u2013a case report","volume":"28","author":"Choudhury M","year":"2007","journal-title":"Trop Gastroenterol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211090"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/15513819409024268"},{"key":"e_1_2_5_15_2","first-page":"606","article-title":"Isolated hepatic mucormycosis in an immunocompetent child","volume":"91","author":"Al Asiri RH","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_16_2","first-page":"511","article-title":"Hepatic mucormycosis in a child with fulminant hepatic failure","volume":"38","author":"Erdem G","year":"1996","journal-title":"Turk J Pediatr"},{"key":"e_1_2_5_17_2","first-page":"294","article-title":"Mucormycosis of the neonatal gastrointestinal tract","volume":"38","author":"Sridhar S","year":"2001","journal-title":"Indian Pediatr"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2000.020107.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211186"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.03.068"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmh077"}],"container-title":["Pediatric Blood &amp; 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