{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:40:12Z","timestamp":1785818412487,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of <jats:italic>Helicobacter pylori<\/jats:italic> eradication on platelet recovery in childhood chronic idiopathic thrombocytopenic purpura (ITP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A multi\u2010center randomized controlled trial was conducted. Patients aged 4\u201318 years, diagnosed with chronic ITP, defined by platelet count below 100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L lasting more than 6 months without identified causes, were enrolled and underwent <jats:sup>13<\/jats:sup>C\u2010urea breath test for diagnosis of <jats:italic>H. pylori<\/jats:italic> infection. Patients who received prednisolone more than 0.5 mg\/kg per day or received other platelet\u2010enhancing therapy were excluded. Patients with <jats:italic>H. pylori<\/jats:italic> infection were randomized into two groups: treatment and control groups. Treatment group received a standard protocol for <jats:italic>H. pylori<\/jats:italic> eradication and repeated <jats:sup>13<\/jats:sup>C\u2010UBT at 4\u20136 weeks to confirm successful therapy while the control group received no specific treatment. Monthly platelet count was monitored for 6 months in both groups. Primary outcome was platelet recovery, defined by platelet count over 100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L for at least 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 55 ITP children, 16 (29.1%) had <jats:italic>H. pylori<\/jats:italic> infection. There were no differences in age, sex, duration of disease, platelet count, and the dose of prednisolone between the treatment group (n\u2009=\u20097) and control group (n\u2009=\u20099). One patient in control group was withdrawn due to massive gastrointestinal bleeding requiring a high dose prednisolone. At 6 months, platelet recovery was demonstrated in one patient in the treatment group as well as one in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No beneficial effect of <jats:italic>H. pylori<\/jats:italic> eradication on platelet recovery in childhood chronic ITP was identified. Pediatr Blood Cancer 2009;53:72\u201377. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21991","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T20:24:21Z","timestamp":1237494261000},"page":"72-77","source":"Crossref","is-referenced-by-count":36,"title":["Absence of platelet recovery following <i>Helicobacter pylori<\/i> eradication in childhood chronic idiopathic thrombocytopenic purpura: A multi\u2010center randomized controlled trial"],"prefix":"10.1002","volume":"53","author":[{"given":"Suporn","family":"Treepongkaruna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nongnuch","family":"Sirachainan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somjai","family":"Kanjanapongkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angkana","family":"Winaichatsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suebsuk","family":"Sirithorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungtip","family":"Sumritsopak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ampaiwan","family":"Chuansumrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200312001-00007"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2008.01.009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.09.014"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60004-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01471.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41641.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400015153"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21125"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-063222"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00238.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20250"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-167155"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04735.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00477.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb02476.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02058.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181615613"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181615600"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10940"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmk003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3201"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70130-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.6.1549"},{"key":"e_1_2_6_26_2","first-page":"1327","article-title":"Prevalence of CagA and VacA genotype of Helicobacter pylori in Thai children","volume":"87","author":"Vivatvakin B","year":"2004","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03194.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0900"}],"container-title":["Pediatric Blood &amp; 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