{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:48:53Z","timestamp":1778543333069,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T00:00:00Z","timestamp":1238630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate late effects and symptom complaints in long\u2010term survivors (&gt;5 years) of Extremity Bone Sarcoma (EBS survivors). The results were compared with findings in age\u2010 and gender\u2010matched individuals from the general population (NORMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Among 155 EBS survivors approached, 133 (86%) were included, and 110 of them (83%) attended an outpatient examination. Health status was evaluated by a mailed questionnaire concerning demographic and current health issues, and physical examinations at the outpatient clinic. Age\u2010 and gender\u2010adjusted normative controls were drawn from participants of the Health Study of Nord\u2010Tr\u00f8ndelag County (HUNT 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at follow\u2010up was 29 (15\u201357) years. Median follow\u2010up was 12 (6\u201322) years. Of EBS survivors 42% had \u22651 somatic disease, 33% had ototoxicity and 13% had reduced renal function. EBS survivors were more likely to have heart disease (odds ratio [OR], 7.9; 95% confidence interval [95% CI], 2.5\u201325.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), hypertension (OR, 3.4; 95% CI, 1.1\u201310.1; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) and thyroid disease (OR, 3.0; 95% CI, 1.1\u20138.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) compared to NORMs. EBS survivors reported more diarrhoea (29% vs. 19%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), palpitations (23% vs. 13%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) and shortness of breath (11% vs. 5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) than NORMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EBS survivors have poorer health status compared to age\u2010 and gender\u2010matched controls. Long\u2010term follow\u2010up of these patients is therefore mandatory. Pediatr Blood Cancer 2009;53:84\u201389. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22027","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:09:20Z","timestamp":1238695760000},"page":"84-89","source":"Crossref","is-referenced-by-count":24,"title":["Health status at long\u2010term follow\u2010up in patients treated for extremity localized Ewing Sarcoma or osteosarcoma: A Scandinavian sarcoma group study"],"prefix":"10.1002","volume":"53","author":[{"given":"L.H.","family":"Aksnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.C.F.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.D.","family":"Foss\u00e5","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Jebsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lernedal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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