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Etoposide, an epipodophyllotoxin, is a topoisomerase II inhibitor that interacts with DNA to potentiate leukaemogenesis. The risk of developing sAML is estimated to be between 1% and 5%, 2\u201320 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co\u2010administration of other antineoplastic agents. Pediatr Blood Cancer 2009;53:488\u2013490. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22063","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T18:25:37Z","timestamp":1242066337000},"page":"488-490","source":"Crossref","is-referenced-by-count":12,"title":["Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis"],"prefix":"10.1002","volume":"53","author":[{"given":"Shanti","family":"RamaChandran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany","family":"Ariffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,11]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2005.00564.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800515)45:10<2516::AID-CNCR2820451008>3.0.CO;2-V"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1182\/blood.V78.1.51.51","article-title":"Treatment of hemophagocytic lymphohistiocytosis with chemotherapy and bone marrow transplantation: A single centre study of 22 cases","volume":"78","author":"Blanche S","year":"1991","journal-title":"Blood"},{"key":"e_1_2_4_5_2","first-page":"331","article-title":"Allogeneic bone marrow transplantation in hemophagocytic lymphohistiocytosis in Sweden","volume":"15","author":"Bolme P","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950220102"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6832.951"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3 <770::AID-CNCR2820651323>3.0.CO;2-8"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112123252402"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210143071601"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb07650.x"},{"key":"e_1_2_4_12_2","first-page":"29","article-title":"Diagnostic guidelines for hemophagocytic lymphohistiocytosis","volume":"18","author":"Henter J\u2010I","year":"1991","journal-title":"Semin Oncol"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe048336"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011001)92:7<1959::AID-CNCR1715>3.0.CO;2-Y"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200102000-00008"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019409141688"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1189"},{"key":"e_1_2_4_18_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1200\/JCO.1999.17.2.569","article-title":"Secondary leukaemia or myelodysplastic syndrome after treatment with epipodophyllotoxin","author":"Smith M","year":"1999","journal-title":"J Clin Oncol"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92779-2"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.100"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.4.1583"},{"key":"e_1_2_4_22_2","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1182\/blood.V89.7.2578","article-title":"Stem cell transplantation for secondary acute myeloid leukaemia: Evaluation of transplantation as initial therapy or following induction chemotherapy","volume":"89","author":"Anderson JE","year":"1997","journal-title":"Blood"}],"container-title":["Pediatric Blood &amp; 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