{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:55:05Z","timestamp":1782824105969,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:00:00Z","timestamp":1245110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["R03-CA-119755"],"award-info":[{"award-number":["R03-CA-119755"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Clinical Research Center","award":["MO1 RR-00043"],"award-info":[{"award-number":["MO1 RR-00043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While carotid artery disease and strokes have been documented in adult cancer patients treated with neck irradiation, little information is available on pediatric patients. The purpose of this study is to determine if carotid disease is more prevalent among pediatric cancer survivors treated with neck irradiation than among healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Thirty pediatric cancer survivors who received neck irradiation (2,000\u20136,660\u2009cGy) and 30 healthy subjects underwent bilateral carotid ultrasounds. Study outcome measures were common carotid intima\u2010media thickness (IMT) and plaque (present or absent). Multivariate methods were used to compare cases and controls and to identify risk factors related to carotid disease in childhood cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IMT was greater for cancer survivors than controls (0.46\u2009mm (SD 0.12) vs. 0.41\u2009mm (SD 0.06), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Plaque was present in 18% of irradiated vessels and 2% of non\u2010irradiated vessels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Among cancer survivors, IMT was positively associated with female gender (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), non\u2010white ethnicity (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), positive family history of stroke\/heart attack (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), BMI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), total cholesterol (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), cancer relapse (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and years off treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Plaque was positively associated with relapse (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and C\u2010reactive protein (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). There was no significant relationship between radiation dose at levels \u22652,000\u2009cGy and IMT or plaque.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Carotid artery disease was more prevalent among cancer survivors treated with neck irradiation than among controls. Due to the high risk of stroke associated with advanced carotid disease, larger prospective studies are needed to better define disease risk in these long\u2010term survivors. Pediatr Blood Cancer 2009;53:615\u2013621. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22111","type":"journal-article","created":{"date-parts":[[2009,7,4]],"date-time":"2009-07-04T09:08:00Z","timestamp":1246698480000},"page":"615-621","source":"Crossref","is-referenced-by-count":36,"title":["Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation"],"prefix":"10.1002","volume":"53","author":[{"given":"Kathleen A.","family":"Meeske","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart E.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Gilsanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sposto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred A.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Lavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.H. 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