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We also analyzed the in vitro drug sensitivity of de novo leukemic blasts among various clinical subsets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to rapid early responders (RERs), slow early responders (SERs) had a significantly greater in vitro drug resistance to dexamethasone (DEX; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) and prednisone (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). The studies with all other drugs showed a non\u2010significant trend with the SER having a higher in vitro drug resistance compared to the RER. Risk group stratified analyses indicated that in vitro resistance to asparaginase (ASP), DEX, and vincristine (VCR) were each significantly related to having very high risk ALL. Additionally, a significantly higher in vitro drug resistance to ASP and VCR was associated with unfavorable lymphoblast genetics and ultimate relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that this FCCA is a potentially simple and rapid method to detect inherent resistance to initial ALL therapy very early in induction, thus allowing for treatment modification shortly thereafter. Pediatr Blood Cancer 2009;53:543\u2013550. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22119","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T16:37:49Z","timestamp":1244133469000},"page":"543-550","source":"Crossref","is-referenced-by-count":10,"title":["Flow cytometric chemosensitivity assay as a predictive tool of early clinical response in acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"53","author":[{"given":"Faith","family":"Galderisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Stork","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motomi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange","family":"Mongoue\u2010Tchokote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1838"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90164-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood.V96.4.1619","article-title":"Accurate 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