{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:44:37Z","timestamp":1773413077002,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:00:00Z","timestamp":1245110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal infections (IFIs) remain a major cause of infectious morality in neutropenic patients receiving chemotherapy or hematopoietic stem cell transplantation (HSCT). Micafungin exhibits broad antifungal activity against both <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> species. We performed a retrospective study to determine the efficacy and safety of prophylactic micafungin against IFI in pediatric neutropenic patients during chemotherapy or HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Forty patients were given micafungin (3\u2009mg\/kg\/day) intravenously for neutropenia: 131 patient\u2010cycles (39 patients) after chemotherapy and 15 patient\u2010cycles (14 patients) after HSCT. Median duration of neutropenia and micafungin prophylaxis was 13 and 23 days after chemotherapy and HSCT, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment success rate, defined as absence of proven, probable, possible, or suspected IFIs, was 93.9% (121\/131) and 80.0% (12\/15) for chemotherapy and HSCT, respectively. Proven or probable IFI was documented in only one patient after HSCT. No adverse events were observed that could be related to micafungin prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that prophylactic micafungin is well tolerated and may prevent IFIs in pediatric patients with neutropenia receiving chemotherapy or HSCT. Pediatr Blood Cancer 2009;53:605\u2013609. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22140","type":"journal-article","created":{"date-parts":[[2009,7,4]],"date-time":"2009-07-04T09:08:00Z","timestamp":1246698480000},"page":"605-609","source":"Crossref","is-referenced-by-count":26,"title":["Antifungal prophylaxis with micafungin in patients treated for childhood cancer"],"prefix":"10.1002","volume":"53","author":[{"given":"Shigenori","family":"Kusuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Hashii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Tokimasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238990"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/340263"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23466"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14472-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.1.53"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/422312"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/527382"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0903.2004.00541.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/496927"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/504810"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1498"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60605-9"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-007-0011-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21868"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00643.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01901-07"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802262123"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/500323"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.004"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm571"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/421944"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/432470"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/588295"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6021"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3317-3324.2005"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21239"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000172751.06286.5b"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg425"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1452-1455.2003"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4895-4902.2005"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:31:57Z","timestamp":1697653917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,18]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/pbc.22140"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22140","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,18]]}}}