{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:56:23Z","timestamp":1783655783788,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T00:00:00Z","timestamp":1247788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with cancer in resource limited countries are often malnourished at diagnosis. Acute malnutrition is associated with more infectious complications and an increased risk of morbidity and mortality in major surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All new patients with the clinical diagnosis of a Wilms tumour admitted in the Queen Elizabeth Central Hospital, Blantyre, Malawi from January 2007 until June 2008 were included. We documented anthropometric parameters, tumour size and serum levels of micronutrients at diagnosis. Corrected weight (body weight\u2009\u2212\u2009tumour weight) was repeated after 4 weeks of preoperative chemotherapy. During therapy oral feeds were encouraged and a locally made ready to use therapeutic peanut butter\u2010based food (chiponde) supplied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A high rate of acute malnutrition was found in patients with Wilms tumour at diagnosis (45\u201355%), much higher than in community controls (11%). Patients (40%) and community controls (37%) had a similar, high rate of stunting (low height for age), a sign of chronic malnutrition. Tumour size at diagnosis and the degree of acute malnutrition at diagnosis was correlated; patients with a larger tumour had more severe acute malnutrition (r\u2009=\u2009\u22120.88, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). With a supply of chiponde, 7 of 18 patients had a &gt;5% increase in corrected weight during preoperative chemotherapy. Patients with a more positive nutritional course had a better tumour response to chemotherapy (r\u2009=\u20090.52, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Surprisingly, few micronutrient deficiencies were found, except for low serum levels of vitamin A (44% of patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute malnutrition, superimposed on chronic malnutrition, is common in patients with Wilms tumour in Malawi. Earlier presentation needs to be encouraged. Chiponde, a peanut butter based ready\u2010to\u2010use\u2010therapeutic\u2010food, is an attractive means of nutritional support which needs further study. Pediatr Blood Cancer 2009; 53:1221\u20131226. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22158","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T19:20:54Z","timestamp":1247858454000},"page":"1221-1226","source":"Crossref","is-referenced-by-count":53,"title":["Acute malnutrition is common in Malawian patients with a Wilms tumour: A role for peanut butter"],"prefix":"10.1002","volume":"53","author":[{"given":"Trijn","family":"Isra\u00ebls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Borgstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Jamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"de Kraker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huib N.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Molyneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011577"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.008"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70092-6"},{"key":"e_1_2_5_5_2","unstructured":"UNICEF.The state of the world's children.2006."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21703"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199277146"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11833"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199277579"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200011000-00005"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198305000-00011"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22032"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.10.007"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61690-0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcn\/32.3.607","article-title":"Physical growth: National Center for Health Statistics percentiles","volume":"32","author":"Hamill PVV","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2540"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.138.2.329"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.488"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265060273S305"},{"key":"e_1_2_5_20_2","article-title":"Preoperative chemotherapy for patients with Wilms tumour in Malawi is feasible, tolerated and efficacious","author":"Israels T","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072727"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/ajcn\/75.6.1057","article-title":"Zinc homeostasis in Malawian children consuming a high\u2010phytate, maize based diet","volume":"75","author":"Manary MJ","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2180"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.322.5898.36"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034306"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890715)64:2<491::AID-CNCR2820640224>3.0.CO;2-Y"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890701)64:1<116::AID-CNCR2820640121>3.0.CO;2-L"},{"key":"e_1_2_5_28_2","first-page":"76","article-title":"Algorithm for nutritional support: Experience of the Metabolic and Infusion support services of St. Jude Children's research hospital","volume":"11","author":"Bowman LC","year":"2008","journal-title":"Int J Cancer Suppl"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607190014003315"}],"container-title":["Pediatric Blood &amp; 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