{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T23:31:27Z","timestamp":1712273487413},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T00:00:00Z","timestamp":1248048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In children &lt;2 years of age, cutaneous involvement is the most frequent presentation of Langerhans cell histiocytosis (LCH). Cutaneous LCH can be localized or associated with dissemination and organ dysfunction. The clinical course is variable, ranging from spontaneous regression to a fatal outcome. We describe a female newborn presenting with congenital cutaneous lesions who rapidly developed pulmonary infiltrates and multiple osteolytic lesions. Skin biopsy showed a dermal infiltrate of medium to large cells morphologically and phenotypically consistent with LCH. The clinical course was rapidly fatal in spite of chemotherapy. No strict correlation between morphology and prognosis has been documented in LCH, but, in our case, distinct morphological and immunohistochemical features (CD56 expression and no E\u2010Cadherin expression) may have contributed to an aggressive clinical course. Pediatr Blood Cancer 2009;53:1107\u20131110. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22196","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T17:18:01Z","timestamp":1248110281000},"page":"1107-1110","source":"Crossref","is-referenced-by-count":6,"title":["Congenital aggressive variant of Langerhans cells histiocytosis with CD56+\/E\u2010Cadherin\u2212 phenotype"],"prefix":"10.1002","volume":"53","author":[{"given":"Marco","family":"Lucioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Beluffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bandiera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frediano","family":"Inzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Fiandrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Viglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Stronati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Necchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Riboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,20]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"358","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe R","year":"2008"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1694"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10166"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1178"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199276921"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2278::AID-CNCR25>3.0.CO;2-U"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111331"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106211"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.7.2073"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<301::AID-PATH779>3.0.CO;2-2"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20362"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20479"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-3027-z"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23645.x"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1999.00856.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.001"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1295"},{"key":"e_1_2_4_21_2","first-page":"2993","article-title":"Prognostic significance of CD56 expression of ALK\u2010positive and ALK\u2010negative anaplastic large cell lymphoma of T\/null cell phenotype","volume":"96","author":"Suzuki R","year":"2000","journal-title":"Blood"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:19:14Z","timestamp":1697653154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,20]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1002\/pbc.22196"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22196","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,20]]}}}