{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:14:23Z","timestamp":1769825663145,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vincristine (VCR) and actinomycin D (ACD) form the backbone of chemotherapeutic regimens of Wilms tumor treatment. Veno\u2010occlusive disease (VOD) is a potentially life\u2010threatening complication of ACD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the incidence of VOD after preoperative chemotherapy and assess the effect of dose and frequency of administrating ACD on the occurrence of VOD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective study of patients where liver biopsies were performed after 4 or 8 weeks of preoperative chemotherapy. Patients had localized or metastatic Wilms tumor and were treated according to SIOP 9, 93\u20101, or 2001 protocol. A correlation was analyzed between histologically confirmed VOD, laboratory parameters, and mode and frequency of ACD administration. Long\u2010term hepatic toxicity was assessed 5 years after the end of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one patients were included in this analysis. Forty\u2010one patients (45.1%) had histological evidence of VOD. The incidence of histologically proven VOD was significantly correlated with single administration of 45\u2009\u00b5g\/kg ACD (SIOP 2001 protocol) as compared to repeated dosing of l5\u2009\u00b5g\/kg (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Fifty\u2010two percent of all patients had mild\u2010to\u2010severe abnormal liver enzymes 5 years after accomplishing therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite short\u2010course preoperative chemotherapy regimen, patients are at risk of developing histological VOD. This risk is higher when ACD is administered in a 1\u2010day 45\u2009\u00b5g\/kg regimen as compared to 3 days l5\u2009\u00b5g\/kg. Pediatr Blood Cancer 2009; 53:1211\u20131215. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22202","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T17:52:54Z","timestamp":1250013174000},"page":"1211-1215","source":"Crossref","is-referenced-by-count":35,"title":["Veno\u2010occlusive disease as a complication of preoperative chemotherapy for Wilms tumor: A clinico\u2010pathological analysis"],"prefix":"10.1002","volume":"53","author":[{"given":"Charissa T.","family":"Jagt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Zuckermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fibo","family":"Ten Kate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.J.M.","family":"Taminiau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel G.W.","family":"Dijkgraaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Heij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"De Kraker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnauld C.","family":"Verschuur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"436p","volume-title":"Cancer in children","author":"Voute PA","year":"2005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.488"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17139-0"},{"key":"e_1_2_6_5_2","first-page":"446","article-title":"Experimental model of hepatic venoocclusive disease (VOD) caused by dactinomycin\u2014Preliminary report about hepatoprotective effect of amifostine","volume":"6","author":"Czauderna P","year":"2000","journal-title":"Med Sci Monit"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<245::AID-MPO2>3.0.CO;2-M"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.9.1525"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198712000-00011"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01695888"},{"key":"e_1_2_6_11_2","first-page":"983","article-title":"Scanning and transmission electron microscopic evaluation of human melanoma cells treated with adriamycin and actinomycin D","volume":"62","author":"Persky B","year":"1983","journal-title":"Scan Electron Microsc"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-004-0902-y"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:10:16Z","timestamp":1697670616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,11]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,12,15]]}},"alternative-id":["10.1002\/pbc.22202"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22202","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,11]]}}}