{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:01:06Z","timestamp":1767650466607},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T00:00:00Z","timestamp":1251676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Aarhus University Hospital's Research Initiative Foundation"},{"name":"Faculty of Health, University of Aarhus"},{"name":"The Family Hede Nielsen's Foundation"},{"name":"Lily Benthine Lunds Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effect of subcutaneous anti\u2010D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty\u2010three children were treated with subcutaneous anti\u2010D 50\u2009\u00b5g\/kg. The median platelet count increased from 7\u2009\u00d7\u200910<jats:sup>9<\/jats:sup> to 31\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L on day 3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The median decline in hemoglobin was 1.3\u2009g\/dl. Two children experienced minor fever and chills within 24\u2009hr of treatment. Pain at the injection site was common but self\u2010limiting with no effect on activity level. These results suggest subcutaneous anti\u2010D IgG 50\u2009\u00b5g\/kg as an effective and well\u2010tolerated treatment option in childhood ITP. Pediatr Blood Cancer 2009; 53:1315\u20131317. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22248","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T18:22:27Z","timestamp":1251742947000},"page":"1315-1317","source":"Crossref","is-referenced-by-count":8,"title":["Subcutaneous anti\u2010D treatment of idiopathic thrombocytopenic purpura in children"],"prefix":"10.1002","volume":"53","author":[{"given":"Mimi","family":"Kjaersgaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille Wendtland","family":"Edslev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320381"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92205-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.2689"},{"key":"e_1_2_6_5_2","first-page":"23","article-title":"Efficacy, safety, and dose response of intravenous anti\u2010D immune globulin (WinRho SDF) for the treatment of idiopathic thrombocytopenic purpura in children","volume":"35","author":"Freiberg A","year":"1998","journal-title":"Semin Hematol"},{"key":"e_1_2_6_6_2","first-page":"265","article-title":"Safety and efficacy of self\u2010administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases","volume":"26","author":"Ochs HD","year":"2006","journal-title":"J Clin Invest"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00244.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.128547"},{"key":"e_1_2_6_10_2","first-page":"887","article-title":"Anti\u2010D immunoglobulin in children with newly diagnosed immune thrombocytopenic purpura: A pilot study","volume":"85","author":"Monteleone PM","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.3.251"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200308000-00017"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90926-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.06.006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-079848"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10065"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1416"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20996"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90346-1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70367-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.11.019"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:12:12Z","timestamp":1697670732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,31]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,12,15]]}},"alternative-id":["10.1002\/pbc.22248"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22248","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,31]]}}}