{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:37:49Z","timestamp":1791095869731,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute Cancer Center CORE Support Grant","award":["P30 CA 21765"],"award-info":[{"award-number":["P30 CA 21765"]}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2009,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New strains of methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) which frequently carry the Panton\u2013Valentine leukocidin (PVL) genes have been recognized to cause invasive infections in otherwise healthy children and adults. However, the epidemiology of PVL\u2010positive MRSA infections has not been described in children or adults with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The epidemiology of MRSA infections in patients with cancer was retrospectively studied from 2000 to 2007. Molecular typing was performed by polymerase chain reaction (PCR) for the detection of the PVL genes. Staphylococcus cassette chromosome (SCC) <jats:italic>mec<\/jats:italic> and <jats:italic>spa<\/jats:italic> typing was performed on all PVL\u2010positive isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88 MRSA isolates from clinically distinct infectious episodes were collected from 88 patients with cancer during the 8\u2010year study period. Infections were predominant in the skin and soft tissues (SSTI; <jats:italic>P<\/jats:italic>\u2009=\u20090.0003). PVL\u2010positive isolates, bearing the type IV SCC<jats:italic>mec<\/jats:italic> element, encoding the gene for methicillin resistance, increased significantly during this period (<jats:italic>P<\/jats:italic>\u2009=\u20090.043) and comprised 35 of 88 (40%) MRSA isolates. Of these 35 isolates, 32 belonged to <jats:italic>spa<\/jats:italic> type 8 and were USA300 genotype. Patients infected with PVL\u2010positive strains did not have more SSTI (<jats:italic>P<\/jats:italic>\u2009=\u20090.166) or bacteremia (<jats:italic>P<\/jats:italic>\u2009=\u20090.510) as compared to patients with PVL\u2010negative strains. A greater percentage of PVL\u2010positive isolates were susceptible to ciprofloxacin (<jats:italic>P<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PVL\u2010positive MRSA infections are not associated with a higher morbidity as compared to PVL\u2010negative MRSA infections in children with cancer. Pediatr Blood Cancer 2009; 53:1216\u20131220. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22254","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T15:57:38Z","timestamp":1251993458000},"page":"1216-1220","source":"Crossref","is-referenced-by-count":14,"title":["Panton\u2013Valentine leukocidin\u2010positive methicillin\u2010resistant <i>Staphylococcus aureus<\/i> infections in children with cancer"],"prefix":"10.1002","volume":"53","author":[{"given":"Ashok","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Seifried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deo K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Shenep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Bankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall T.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"707","article-title":"Four pediatric deaths from community acquired methicillin\u2010resistant Staphylococcus aureus\u2014Minnesota and North Dakota, 1997\u20131999","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.8.593"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.030089"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/425019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/313461"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.1.108-118.2006"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/344326"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2976"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)24468-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/509506"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042683"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000133044.79130.2a"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2300"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","unstructured":"Clinical Laboratory Standards Institute (CLSI).Performance standards for antimicrobial susceptibility testing. 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