{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:44:09Z","timestamp":1776408249221,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>High birth weight (HBW) is an established risk factor for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to evaluate if birth weight (BW) corrected\u2010for\u2010gestational age is a better predictor than BW alone for occurrence of ALL and other malignancies in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Birth certificate data of 2,254 children with cancer who were younger than 5 years old at diagnosis and registered at Texas Cancer Registry during 1995\u20132003 were compared to 11,734 age\u2010matched controls. Multivariable logistic regression was used to compare models with BW corrected\u2010for\u2010gestational age and BW alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to children who were appropriate for gestational age (AGA), children who were large for gestational age (LGA) at birth had a 1.66 times (95% CI 1.32\u20132.10) higher odds of ALL. Similarly, children with a BW \u22654,000\u2009g had a 1.5 times (95% CI 1.18\u20131.89) higher odds for ALL, compared to children who weighed &gt;2,500 and &lt;4,000\u2009g at birth. Using model diagnostics, the model containing BW corrected\u2010for\u2010gestational age was a better predictor than the model with BW alone [Akaike's Information Criterion (AIC) 4,646 vs. 4,658, respectively]. Odds ratios (OR) were similar for LGA children who were &lt;4,000\u2009g and LGA children who were \u22654,000\u2009g (OR\u2009=\u20091.5, 95% CI 0.97\u20132.5 and OR\u2009=\u20091.67, 95% CI 1.29\u20132.16, respectively). BW was not an independent risk factor for acute myeloid leukemia or brain tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BW corrected\u2010for\u2010gestational age is a better predictor than BW alone of risk for ALL. Future studies using BW variable should incorporate gestational age in their analyses. Pediatr Blood Cancer 2010;54:242\u2013249. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22308","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T16:57:24Z","timestamp":1254934644000},"page":"242-249","source":"Crossref","is-referenced-by-count":44,"title":["Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors"],"prefix":"10.1002","volume":"54","author":[{"given":"Michael R.","family":"Sprehe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Barahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele R.","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Bondy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Fatih","family":"Okcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019555912243"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6<1351::AID-CNCR2820680627>3.0.CO;2-J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.541"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880018709141250"},{"key":"e_1_2_6_6_2","first-page":"1039","article-title":"Birth weight and the incidence of childhood cancer","volume":"72","author":"Daling JR","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70091-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.13.939"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.631"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(97)00012-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197303000-00005"},{"key":"e_1_2_6_12_2","first-page":"441","article-title":"Prenatal and neonatal risk factors for childhood myeloid leukemia","volume":"4","author":"Cnattingius S","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.12.908"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.603"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113799"},{"key":"e_1_2_6_16_2","first-page":"3696","article-title":"Maternal and perinatal risk factors for childhood leukemia","volume":"51","author":"Zack M","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019409141806"},{"key":"e_1_2_6_18_2","first-page":"231","article-title":"Birth characteristics of children dying of malignant neoplasms","volume":"28","author":"Macmahon B","year":"1962","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24225"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051889"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70404-X"},{"key":"e_1_2_6_22_2","first-page":"802","article-title":"The cell type\u2010specific IGF2 expression during early human development correlates to the pattern of overgrowth and neoplasia in the Beckwith\u2010Wiedemann syndrome","volume":"145","author":"Hedborg F","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200209000-00027"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1210\/jcem.86.2.7217","article-title":"Cord blood leptin and insulin\u2010like growth factor levels are independent predictors of fetal growth","volume":"86","author":"Christou H","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01167.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993893"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.3.289"},{"key":"e_1_2_6_28_2","first-page":"489","article-title":"Placental leptin correlates with intrauterine fetal growth and development","volume":"81","author":"Ben X","year":"2001","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00992-3"},{"key":"e_1_2_6_30_2","first-page":"135","article-title":"Study on the relationship between epidermal growth factor and fetal growth retardation","volume":"34","author":"Dong M","year":"1999","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022381506823"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm065"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9011-y"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600192"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-008-0390-9"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.096"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh137"},{"key":"e_1_2_6_41_2","first-page":"332","article-title":"Intrauterine growth retardation (IUGR): Epidemiology and etiology","volume":"6","author":"Romo A","year":"2009","journal-title":"Pediatr Endocrinol Rev"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:25:33Z","timestamp":1696879533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/pbc.22308"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22308","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,7]]}}}