{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:16Z","timestamp":1761058996630},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinically apparent jaundice is unusual in patients with \u03b2\u2010thalassemia major. Co\u2010inheritance of Gilbert syndrome has been reported to cause hyperbilirubinemia in these subjects. Crigler\u2013Najjar syndrome is another rare disorder of bilirubin metabolism caused by mutation in the gene coding the enzyme UGT1A1. We report a patient of \u03b2\u2010thalassemia major who presented with persistent jaundice due to co\u2010inherited Crigler\u2013Najjar syndrome type 2 secondary to a novel mutation in UGT1A1 gene [homozygous base substitution at position 362 (GGT&gt;AGT) in exon 3]. Pediatr Blood Cancer 2010;54:627\u2013628. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22313","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T18:49:26Z","timestamp":1259693366000},"page":"627-628","source":"Crossref","is-referenced-by-count":4,"title":["Persistent jaundice in an infant with homozygous beta thalassemia due to co\u2010inherited Crigler\u2013Najjar syndrome"],"prefix":"10.1002","volume":"54","author":[{"given":"Varun","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Seth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satinder","family":"Aneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Sammarco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Fabiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"103","article-title":"Co\u2010inherited Gilbert's syndrome: A factor determining hyperbilirubinemia in homozygous \u03b2 thalassemia","volume":"84","author":"Galanello R","year":"1999","journal-title":"Hematologica"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800101753328439"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.4113228.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3703182.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-9796(03)00118-9"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.3.250"},{"key":"e_1_2_4_8_2","first-page":"306","article-title":"Homozygous beta thalassemia presenting as neonatal jaundice","volume":"45","author":"Hazir T","year":"1995","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z"},{"key":"e_1_2_4_10_2","unstructured":"The Human Gene Mutation Database at the Institute of medical genetics in Cardiff: Gene symbol UGT1A1 downloaded on 22\/03\/2009."}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:55:25Z","timestamp":1696866925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1002\/pbc.22313"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22313","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}