{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:43:36Z","timestamp":1761101016784},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T00:00:00Z","timestamp":1257897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is paucity of data on long\u2010term probability of remission in chronic idiopathic thrombocytopenic purpura (ITP). Aim was to study the course and factors influencing remission of chronic ITP. Chronic ITP was defined as thrombocytopenia persisting &gt;6 months following initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Case\u2010records of children with chronic ITP, aged &lt;14 years, were reviewed in this retrospective study (1987\u20132006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred seventy children were followed. Median age at diagnosis was 6 years. Median duration of follow up was 30 months (range 6\u2013166). Isolated thrombocytopenia (even if &lt;10\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) in the absence of \u201csignificant\u201d bleeds, by itself was not considered an indication for drug therapy. Sixty\u2010seven (24.8%) children attained complete remission (CR) over a median period of 18 months (range 7\u2013120). The probabilities of remission at 5 years for males and females were 24% and 39.6%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The probability of achieving remission at 10 years in children &lt;8 and \u22658 years was 51.2% and 34%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). The probability of remission at 5 years for children who received some treatment, versus no treatment was 31.4% and 27%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.8). Nine of 18 children, who underwent splenectomy, achieved CR. Intracranial hemorrhage (ICH) occurred in 11 (4%) cases. The time of occurrence of ICH from onset of symptoms varied from 6 to 55 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The predicted spontaneous remission rate with chronic ITP was 30% and 44% at 5 and 10 years, respectively. Platelet count at diagnosis and the treatment administered did not influence remission outcomes. Age &lt;8 years and female gender were predictors of a favorable outcome. Pediatr Blood Cancer 2010;54:403\u2013407. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22346","type":"journal-article","created":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T19:08:00Z","timestamp":1257966480000},"page":"403-407","source":"Crossref","is-referenced-by-count":42,"title":["Outcome of chronic idiopathic thrombocytopenic purpura in children"],"prefix":"10.1002","volume":"54","author":[{"given":"Deepak","family":"Bansal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanmay Anant","family":"Bhamare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Trehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.K.","family":"Marwaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13175.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04143-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21569"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.2.125"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200312001-00007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20995"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21872"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200411000-00007"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125909"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21621"},{"key":"e_1_2_5_12_2","first-page":"504","article-title":"Long\u2010term follow\u2010up of idiopathic thrombocytopenic purpura in 310 patients","volume":"86","author":"Vianelli N","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204392"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.1.3.3"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70431-4"},{"key":"e_1_2_5_16_2","first-page":"468","article-title":"Spontaneous intracranial hemorrhage in children with immune thrombocytopenic purpura","volume":"39","author":"Arya LS","year":"2002","journal-title":"Indian Pediatr"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21728"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.3.251"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:17:24Z","timestamp":1697674644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,11]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/pbc.22346"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22346","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,11]]}}}