{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:38Z","timestamp":1791125618951,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vanderbilt Ingram Cancer Center National Cancer Institute","award":["CA068485"],"award-info":[{"award-number":["CA068485"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Research on the physical and psychological late effects of treatment of childhood cancer has led to the identification of significant long\u2010term neurocognitive deficits experienced by some survivors, particularly in the areas of memory and executive functioning. Despite indications of deficits based on cognitive assessment, the identification of specific mechanisms of neurocognitive deficits using neuroimaging techniques has yet to be adequately considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This study used functional neuroimaging techniques to examine working memory and executive functioning deficits of survivors of childhood acute lymphocytic leukemia (ALL), as compared to age\u2010 and gender\u2010matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a trend for ALL survivors to perform more poorly on a working memory task in terms of overall accuracy. Additionally, survivors displayed significantly greater activation in areas underlying working memory (dorsolateral and ventrolateral prefrontal cortex) and error monitoring (dorsal and ventral anterior cingulate cortex).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results support the theory of compensatory activation in necessary brain regions in order to complete tasks in pediatric ALL survivors, similar to that observed in multiple sclerosis patients. Concurrent examination of testing and brain imaging enables the connection of behavioral observations with underlying neurological characteristics of deficits in survivors and may help provide insight into mechanisms through which deficits appear. Pediatr Blood Cancer 2010;54:585\u2013590. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22362","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T18:49:59Z","timestamp":1259693399000},"page":"585-590","source":"Crossref","is-referenced-by-count":64,"title":["Working memory in survivors of childhood acute lymphocytic Leukemia: Functional neuroimaging analyses"],"prefix":"10.1002","volume":"54","author":[{"given":"Kristen E.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Livesay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Scaduto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Cannistraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Whitlock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Compas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20860"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21544"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20131"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199706)28:6<387::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.04.024"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0904"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10210"},{"key":"e_1_2_6_9_2","volume-title":"Wechsler Intelligence Scale for Children\u2014Fourth Edition: Technical and interpretive manual","author":"Wechsler D","year":"2003"},{"key":"e_1_2_6_10_2","volume-title":"Examiner's manual for the Delis\u2010Kaplan executive function system","author":"Delis DC","year":"2001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01674-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20249"},{"key":"e_1_2_6_13_2","volume-title":"Co\u2010planar Stereotaxic Atlas of the Human Brain. 3\u2010dimensional Proportional System: An approach to cerebral imaging","author":"Talairach TJ","year":"1988"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2004.00745.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.035"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.39.4.761"},{"key":"e_1_2_6_17_2","first-page":"105","volume-title":"Handbook of child psychology: Social, emotional, and personality development","author":"Rothbart MK","year":"1998"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6916.2007.00032.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1176\/jnp.17.3.357","article-title":"Magnetic resonance spectroscopy of memory and frontal brain region in early multiple sclerosis","volume":"17","author":"Staffen W","year":"2005","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_6_20_2","unstructured":"LivesayKL RobinsonKE CampbellLK et al.Neurocognitive effects in childhood survivors of acute lymphocytic leukemia: A functional neuroimaging study of inhibitory interference control. 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