{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:22Z","timestamp":1761059002477},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ehrlichiosis, a tickborne illness transmitted by tick vectors <jats:italic>Amblyomma americanum<\/jats:italic> and <jats:italic>Ixodes scapularis<\/jats:italic>, can be acquired in endemic areas. Clinical manifestations range from asymptomatic to fulminant in nature. We report three cases of ehrlichiosis in pediatric oncology patients, one of whom was a stem cell transplant recipient. Early symptoms included fever, malaise, and vague gastrointestinal symptoms. Laboratory abnormalities were initially attributed to chemotherapy toxicity. Illness was severe in all three patients and one patient died even after initiation of doxycycline. These cases emphasize the need for a high index of suspicion for tickborne illness in oncology patients, and the importance of a low threshold for starting empiric treatment before confirming the diagnosis. Pediatr Blood Cancer 2010;54:776\u2013778. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22392","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T22:31:56Z","timestamp":1262730716000},"page":"776-778","source":"Crossref","is-referenced-by-count":13,"title":["Severe ehrlichia infection in pediatric oncology and stem cell transplant patients"],"prefix":"10.1002","volume":"54","author":[{"given":"Adam","family":"Esbenshade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Esbenshade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Domm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydar","family":"Frangoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200002000-00023"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/518146"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00373.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/323981"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291605"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200002000-00021"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010249"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318042b66c"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0909.020560"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200106150-00030"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01821.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.2.166"},{"key":"e_1_2_4_14_2","first-page":"1","article-title":"Diagnosis and management of tickborne rickettsial diseases: Rocky mountain spotted fever, ehrlichioses, and anaplasmosis\u2014United States: A practical guide for physicians and other health\u2010care and public health professionals","volume":"55","author":"Chapman AS","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07341.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.1.e10"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800075"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200102000-00028"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318168da1d"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200507030-00003"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:32:19Z","timestamp":1697675539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/pbc.22392"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22392","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,4]]}}}