{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:43:36Z","timestamp":1697705016422},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T00:00:00Z","timestamp":1262563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Protoplasmic astrocytoma is an extremely rare form of grade II low grade glioma which usually presents as a discrete mass lesion. We describe a 3\u2010year\u2010old female with diffuse protoplasmic astrocytoma with parenchymal involvement and leptomeningeal spread. This tumour proved extremely difficult to diagnose and followed a progressive course. Three superficial biopsies did not give the diagnosis and this was only confirmed 8 months from presentation from a larger fourth biopsy taken deeper from the cerebellum. To our knowledge this case represents the distinct presentation of protoplasmic astrocytoma presenting as extensive diffuse meningeal disease. Pediatr Blood Cancer 2010;54:768\u2013769. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22402","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T17:16:59Z","timestamp":1262625419000},"page":"768-769","source":"Crossref","is-referenced-by-count":4,"title":["Diffuse central nervous system protoplasmic astrocytoma"],"prefix":"10.1002","volume":"54","author":[{"given":"Sue","family":"Manley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Crooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libby","family":"Artingstall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Buxton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Riordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Pizer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"e_1_2_4_2_2","volume-title":"WHO classification of tumours of the central nervous system","author":"Louis DN","year":"2007"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.6.705"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/65.4.352"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01402086"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2000.92.1.0109"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/PED.2008.2.12.402"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199906000-00006"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2008.01.036"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.120"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:31:55Z","timestamp":1697675515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,4]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/pbc.22402"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22402","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,4]]}}}