{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T17:47:21Z","timestamp":1743011241036},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T00:00:00Z","timestamp":1267660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyponatremia is a common metabolic disorder in cancer patients. However, little information is available for patients receiving chemotherapy or stem cell transplantation (SCT). We analyzed the frequency, characteristics, and various causes of hyponatremia including routine use of hypotonic fluids in children following chemotherapy or SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We reviewed the clinical and laboratory data of 63 children who received chemotherapy or SCT at the Department of Pediatrics, Hanyang University Medical Center from July 2005 to July 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 63 patients at admission received routine parenteral fluids of 0.25% or 0.45% NaCl and 82 episodes of hyponatremia were observed in 40 (63.5%) patients. Of these 82 episodes, 50 episodes of hyponatremia developed in 29 children following chemotherapy and 32 episodes in 16 children following SCT. Seventy\u2010six out of 82 episodes (92.7%) of hyponatremia developed in 37 patients receiving hypotonic fluids with NaCl concentrations between 30 and 150\u2009mEq\/L. The frequency of SIADH in the SCT setting was more frequent (14\/21, 66.6%) than in the chemotherapy setting (18\/58, 31.0%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), even though the leading cause of hyponatremia was SIADH in both settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SIADH is a leading cause of hyponatremia in children following chemotherapy or SCT, and more frequent in SCT settings than in chemotherapy settings. Furthermore, the routine use of hypotonic fluids which could aggravate the development of hyponatremia for these patients should be avoided and then switched to isotonic fluids. Pediatr Blood Cancer 2010;54:734\u2013737. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22442","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T20:09:24Z","timestamp":1267733364000},"page":"734-737","source":"Crossref","is-referenced-by-count":9,"title":["Syndrome of inappropriate secretion of antidiuretic hormone as a leading cause of hyponatremia in children who underwent chemotherapy or stem cell transplantation"],"prefix":"10.1002","volume":"54","author":[{"given":"Yeon\u2010Jung","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Kyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Chul","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"504","article-title":"Metabolic emergencies in clinical oncology","volume":"16","author":"Silverman P","year":"1989","journal-title":"Semin Oncol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1188\/03.CJON.425-430"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050284"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.2.227"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0526"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31818d3192"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.088690"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199408000-00004"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289203100305"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90096-4"},{"key":"e_1_2_5_12_2","first-page":"625","article-title":"Management of the syndrome of inappropriate secretion of antidiuretic hormone","volume":"6","author":"Kinzie BJ","year":"1987","journal-title":"Clin Pharm"},{"key":"e_1_2_5_13_2","first-page":"373","article-title":"Syndrome of inappropriate antidiuretic hormone: Assessment and nursing implications","volume":"16","author":"Poe CM","year":"1989","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008369932384"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868909092315"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200208000-00005"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869509093969"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2003.n.033"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1995.tb00907.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01788840"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019509029586"},{"key":"e_1_2_5_22_2","first-page":"353","article-title":"Syndrome of inappropriate ADH secretion: A late complication of hemopoietic stem cell allograft","volume":"19","author":"Festuccia F","year":"2002","journal-title":"G Ital Nefrol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704688"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36873-0"},{"key":"e_1_2_5_25_2","first-page":"2387","article-title":"Management of hyponatremia","volume":"69","author":"Goh KP","year":"2004","journal-title":"Am Fam Phys"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1188\/03.CJON.425-430"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.026"}],"container-title":["Pediatric Blood &amp; 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