{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:56:12Z","timestamp":1761540972367},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T00:00:00Z","timestamp":1268611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A potential long\u2010term complication of central venous catheter (CVC)\u2010related deep vein thrombosis (DVT), both symptomatic and asymptomatic, is development of post\u2010thrombotic syndrome (PTS) characterized by persistent pain, swelling, and skin changes. Signs and symptoms of PTS were reported after CVC removal. The aim of this study was to assess the risk factors for development of PTS in childhood cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Children followed at the after cancer follow\u2010up clinic were enrolled. The patients were screened for PTS using Kuhle's PTS pediatric score. Patient's records were retrospectively reviewed for clinical and CVC\u2010related data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one children were enrolled at a median of 2.3 (range 0.33\u20137.5) years after removal of their CVC. The median age of the children the time of treatment was 6.5 (range 0.25\u201318) years. Mild PTS was present in 20 children (39%, 95% CI 26\u201354%). Pain symptoms were reported in five children (9.5%, 95% CI 3.3\u201321.4%). Higher rate of PTS was found in children with history of CVC occlusion. The odd ratio (95% CI) for PTS in children with history of occlusion was 3.7 (95% CI 1.1\u201312.5%) (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). The occurrence of PTS was not associated with age at the time of treatment, time from CVC removal, duration of CVC, and history of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Screening cancer survivors for PTS after CVC removal should be integrated to the after cancer follow\u2010up clinic. Obstruction of CVC may indicate for asymptomatic DVT. Whether thromboprophylaxis and\/or prevention of CVC occlusion can decrease the rate of PTS needs to be studied. Pediatr Blood Cancer 2010;55:153\u2013156. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22459","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T17:37:27Z","timestamp":1268674647000},"page":"153-156","source":"Crossref","is-referenced-by-count":20,"title":["Post\u2010thrombotic syndrome after central venous catheter removal in childhood cancer survivors is associated with a history of obstruction"],"prefix":"10.1002","volume":"55","author":[{"given":"Shoshana","family":"Revel\u2010Vilk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motti","family":"Menahem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanie","family":"Stoffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood.V93.5.1595","article-title":"Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors","volume":"93","author":"Nowak\u2010Gottl U","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014341"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111272"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11042"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70149-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02901.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.05.029"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0309-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.09.008"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.3.212"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127276"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.09.033"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/08035250500499457"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.5343"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02445.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03002.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510370066034"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.5600"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2006.01623.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03294.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03339.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061234"},{"key":"e_1_2_6_24_2","first-page":"2979","article-title":"Post\u2010thrombotic syndrome affecting the upper venous system in children: Validation of outcome measurements and application in a single\u2010institutional prospective inception cohort study","volume":"114","author":"Goldenberg NA","year":"2009","journal-title":"ASH Annual Meeting Abstracts"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200006000-00013"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318162bcf5"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/08035250600746328"}],"container-title":["Pediatric Blood &amp; 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