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While prolonged systemic administration of corticosteroids is known to suppress the hypothalamic\u2013pituitary\u2013adrenal axis, there have been no reports describing this effect following administration of ITT. We present an infant with relapsed acute myelogenous leukemia who developed clinically significant central adrenal axis suppression following six doses of ITT over 3 weeks, proven by corticorelin stimulation test. As multiple pediatric leukemia protocols incorporate ITT, particularly in infants, we feel that ITT should be considered as a potential source of adrenal axis suppression. Pediatr Blood Cancer. 2010;55:386\u2013389. \u00a9 2010 Wiley\u2013Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22533","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T19:43:48Z","timestamp":1273088628000},"page":"386-389","source":"Crossref","is-referenced-by-count":3,"title":["Secondary adrenal insufficiency in an infant after intrathecal triple chemotherapy"],"prefix":"10.1002","volume":"55","author":[{"given":"Alix E.","family":"Seif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Rheingold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403924"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199805000-00008"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200103040-00001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860401)57:7<1287::AID-CNCR2820570706>3.0.CO;2-O"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-1-11"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-1-11"},{"key":"e_1_2_5_8_2","first-page":"694","article-title":"Treatment of poor risk acute leukemia with sequential high\u2010dose ARA\u2010C and asparaginase","volume":"63","author":"Capizzi RL","year":"1984","journal-title":"Blood"},{"key":"e_1_2_5_9_2","first-page":"1110","article-title":"Trans\u2010sacral injection; clinical and radiological study","volume":"73","author":"Lievre J","year":"1957","journal-title":"Bull Mem Soc Med Hop Paris"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2253011401"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.4.0567"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460070074007"},{"key":"e_1_2_5_13_2","first-page":"29","article-title":"Duration of action of epidural methyl prednisolone. 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