{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:14:47Z","timestamp":1790421287845,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Berliner Krebsgesellschaft","award":["HUFF200803"],"award-info":[{"award-number":["HUFF200803"]}]},{"name":"Deutsche Jos\u00e9 Carreras Leuk\u00e4mie Stiftung","award":["DJCLS R 09\/27"],"award-info":[{"award-number":["DJCLS R 09\/27"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resistance to glucocorticoid induced apoptosis is one of the major risk factors for relapse and poor outcome in childhood acute lymphoblastic leukemia (ALL). Overexpression of X\u2010linked inhibitor of apoptosis protein (XIAP) has been shown to be associated with chemotherapy resistance in several malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>XIAP protein and mRNA expression were determined in leukemic blasts of 51 childhood ALL patients and normal bone marrow mononuclear cells. XIAP expression was correlated with glucocorticoid response and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      XIAP protein but not mRNA expression was found to be highly increased in childhood ALL compared to control bone marrow mononuclear cells (MNC) (median: 3.5 vs. 0.14\u2009ng\/10\n                      <jats:sup>5<\/jats:sup>\n                      MNC,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) indicating a post\u2010transcriptional regulation of XIAP expression. In patients with T\u2010cell ALL, poor prednisone response was associated with increased XIAP expression (median: 2.8 in good vs. 5.8 in poor responders;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005). Similarly, T\u2010cell ALL patients suffering adverse events showed higher initial XIAP levels than patients in continuous complete remission (CCR) (median: 2.7 in patients in CCR vs. 5.6 in patients suffering adverse events;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). XIAP inhibition using the low\u2010molecular\u2010weight SMAC mimetic LBW242 resulted in a significant increase of prednisone\u2010induced apoptosis in vitro.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In childhood ALL compared to control bone marrow, the expression of the apoptosis inhibitor XIAP is highly increased by post\u2010transcriptional regulation. The association with poor in vivo glucocorticoid response and outcome in T\u2010cell ALL suggests XIAP inhibition as a promising novel approach for the treatment of resistant ALL. Pediatr Blood Cancer. 2010;55:260\u2013266. \u00a9 2010 Wiley\u2013Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.22541","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T15:45:02Z","timestamp":1273074302000},"page":"260-266","source":"Crossref","is-referenced-by-count":38,"title":["XIAP expression is post\u2010transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T\u2010cell ALL"],"prefix":"10.1002","volume":"55","author":[{"given":"Patrick","family":"Hundsdoerfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Schmelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Henze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1031"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112920"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.4.1209"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35080103"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161506698"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5429-5444.2005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00008-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00341-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35055027"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/11109"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21905"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000464"},{"key":"e_1_2_6_15_2","first-page":"1796","article-title":"Expression 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