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Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL\u2010directed therapy and HLH\u2010directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post\u2010transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658\u2013660. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22688","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T15:03:59Z","timestamp":1291734239000},"page":"658-660","source":"Crossref","is-referenced-by-count":19,"title":["Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"56","author":[{"given":"Caitlin","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"McClain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammar","family":"Hayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20950"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181864ab9"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90157-0"},{"key":"e_1_2_4_6_2","first-page":"1262","article-title":"Histiocytic medullary reticulosis in acute lymphoblastic leukemia of T cell origin","volume":"130","author":"Chen T","year":"1976","journal-title":"Am J Dis Child"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90590-9"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197805)41:5<1967::AID-CNCR2820410542>3.0.CO;2-7"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810201)47:3<537::AID-CNCR2820470319>3.0.CO;2-5"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860915)58:6<1289::AID-CNCR2820580619>3.0.CO;2-H"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870201)59:3<424::AID-CNCR2820590312>3.0.CO;2-J"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500160017"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050498"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830115)51:2<200::AID-CNCR2820510204>3.0.CO;2-C"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00203-9"},{"key":"e_1_2_4_16_2","first-page":"975","article-title":"B precursor lymphoblastic leukemia\/lymphoma manifested at onset of hemophagocytic syndrome","volume":"48","author":"Nishiki S","year":"2000","journal-title":"Rinsho Byori"},{"key":"e_1_2_4_17_2","first-page":"58","article-title":"Development of acute lymphoblastic leukemia following bacterial tonsillitis in acute lymphoblastic leukemia","volume":"70","author":"Suzuki T","year":"1999","journal-title":"Int J Hematol"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000079078"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20771"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0208-y"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22064"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22688","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:27:44Z","timestamp":1700490464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/pbc.22688"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22688","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,7]]}}}