{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:00:26Z","timestamp":1781028026680,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unstable hemoglobin variants represent a rare etiology of congenital hemolytic anemia. Without a high index of suspicion, plus proper laboratory testing and interpretation, the correct diagnosis can be elusive. We report on five children who were initially thought to have other congenital disorders such as hereditary spherocytosis or thalassemia, before \u03b2\u2010globin gene sequencing led to the definitive diagnosis. Recognizing the variable clinical presentation and laboratory data reported will aid clinicians in diagnosis of unstable hemoglobins variants in children with atypical forms of hemolytic anemia, particularly those with low pulse oximetry values or whose hemoglobin electrophoresis suggest \u03b2\u2010thalassemia trait. Pediatr Blood Cancer. 2010;55:1393\u20131395. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22702","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T10:11:17Z","timestamp":1285927877000},"page":"1393-1395","source":"Crossref","is-referenced-by-count":22,"title":["The diagnostic dilemma of congenital unstable hemoglobinopathies"],"prefix":"10.1002","volume":"55","author":[{"given":"Amber M.","family":"Yates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Mortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina S.","family":"Hyde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell E.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Rudolph's pediatrics","author":"Yates AM","year":"2010"},{"key":"e_1_2_6_3_2","first-page":"613","volume-title":"Nathan and Oski's Hematology of infancy and childhood","author":"Ware RE","year":"2009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10044"},{"key":"e_1_2_6_5_2","first-page":"2643","article-title":"An electronic database of human hemoglobin variants on the World Wide Web","volume":"91","author":"Chui DH","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_6_2","first-page":"645","volume-title":"Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias. 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