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The G6PD Cincinnati mutation results in a non\u2010conservative amino acid substitution at the tetramer interface disturbing its formation, as seen by native gel electrophoresis and immunoblotting. G6PD Gastonia disrupts dimerization of the enzyme and by itself causes chronic non\u2010spherocytic hemolytic anemia. The G6PD Cincinnati mutation may have aggravated the clinical picture of G6PD Gastonia with the result of severe perinatal hemolysis causing cholestasis and associated liver injury. Pediatr Blood Cancer 2011;56:840\u2013842. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22744","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T19:34:29Z","timestamp":1287084869000},"page":"840-842","source":"Crossref","is-referenced-by-count":9,"title":["Cooperating G6PD mutations associated with severe neonatal hyperbilirubinemia and cholestasis"],"prefix":"10.1002","volume":"56","author":[{"given":"Benjamin","family":"Mizukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvarnamala","family":"Pushkaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Weckbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KarenAnn","family":"Kalinyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Heubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodosia A.","family":"Kalfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-077412"},{"key":"e_1_2_5_3_2","first-page":"601","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency. 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