{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:59:10Z","timestamp":1762541950906},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T00:00:00Z","timestamp":1283990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study is to determine whether height measurements are affected by cranial radiation doses of 12\u201318\u2009Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>From 1997 to 2007, 23 children received cranial RT for T\u2010cell or pre\u2010B\u2010cell acute lymphoblastic leukemia (ALL). Dose fractionation schemes included 18\u2009Gy in 9 fractions (n\u2009=\u20098), 18\u2009Gy in 10 fractions (n\u2009=\u20095), 12.6\u2009Gy in 7 fractions (n\u2009=\u20096), and 12\u2009Gy in 8 fractions (n\u2009=\u20094). These patients were matched and compared to a control group of 23 patients who had ALL but no cranial RT. Height <jats:italic>z<\/jats:italic>\u2010scores at diagnosis and last follow\u2010up were compared using the paired Student's <jats:italic>t<\/jats:italic>\u2010test. Differences in <jats:italic>z<\/jats:italic>\u2010scores according to host and treatment parameters were compared using the unpaired Student's <jats:italic>t<\/jats:italic>\u2010test. Median follow\u2010up for irradiated patients was 63.5 months while for unirradiated patients was 91 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:italic>z<\/jats:italic>\u2010scores at initial diagnosis and last follow\u2010up were 0.14 and \u22120.48 for patients receiving 12\u201312.6\u2009Gy (<jats:italic>P<\/jats:italic>\u2009=\u20090.016), \u22120.16 and \u22120.89 for 18\u2009Gy (<jats:italic>P<\/jats:italic>\u2009=\u20090.003), and 0.34 and 0.22 for no RT (<jats:italic>P<\/jats:italic>\u2009=\u20090.62). For children receiving RT, the mean difference in <jats:italic>z<\/jats:italic>\u2010scores at initial diagnosis and last follow\u2010up was \u22120.67 while for those not receiving RT, it was \u22120.10 (<jats:italic>P<\/jats:italic>\u2009=\u20090.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children receiving 12\u201318\u2009Gy cranial RT for ALL were found to have height impairment compared to those not receiving RT. Pediatr Blood Cancer 2011;56:279\u2013281. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22781","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T20:40:55Z","timestamp":1284064855000},"page":"279-281","source":"Crossref","is-referenced-by-count":5,"title":["Height impairment after lower dose cranial irradiation in children with acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"56","author":[{"given":"Arnold C.","family":"Paulino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Jhaveri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoann","family":"Dreyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin S.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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