{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:44:31Z","timestamp":1787777071728,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T00:00:00Z","timestamp":1287705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histiocytic sarcoma (HS) is a rare malignancy of tissue histiocytes with a dismal prognosis. We report a 4\u2010year\u2010old male who developed HS during maintenance chemotherapy for precursor B\u2010cell acute lymphoblastic leukemia (pre\u2010B ALL). Both tumors showed identical clonal immunoglobulin and T\u2010cell receptor gene re\u2010arrangement patterns, as well as homozygous deletion of the <jats:italic>CDKN2A<\/jats:italic> gene encoding p16<jats:sup>INK4A<\/jats:sup>. These data suggest a clonal relationship between the two neoplasms despite their distinct lineages. Since <jats:italic>CDKN2A<\/jats:italic> deletion predisposes to development of HS in experimental models, the cytogenetic features of the patient's pre\u2010B ALL may have predisposed to this change in lineage. Pediatr Blood Cancer 2011;56:307\u2013310. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22810","type":"journal-article","created":{"date-parts":[[2010,10,23]],"date-time":"2010-10-23T01:43:32Z","timestamp":1287798212000},"page":"307-310","source":"Crossref","is-referenced-by-count":60,"title":["Pediatric histiocytic sarcoma clonally related to precursor B\u2010cell acute lymphoblastic leukemia with homozygous deletion of <i>CDKN2A<\/i> encoding p16<sup>INK4A<\/sup>"],"prefix":"10.1002","volume":"56","author":[{"given":"Riten","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila P.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya\u2010Devi","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene R.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,22]]},"reference":[{"key":"e_1_2_4_2_2","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00419-2"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1182\/blood.V87.12.5207.bloodjournal87125207","article-title":"True histiocytic lymphoma following therapy for lymphoblastic neoplasms","volume":"87","author":"Soslow RA","year":"1996","journal-title":"Blood"},{"key":"e_1_2_4_5_2","first-page":"78","article-title":"T\u2010lymphoblastic lymphoma terminating as malignant histiocytosis with rearrangement of immunoglobulin heavy chain gene","volume":"5","author":"van der Kwast TH","year":"1991","journal-title":"Leukemia"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01428-7"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.08.020"},{"key":"e_1_2_4_8_2","first-page":"1","article-title":"Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature","volume":"2009","author":"Costa da Cunha Castro E","journal-title":"Pediatr Dev Pathol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800346"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0026"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318180bb95"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.03.028"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166801"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02841.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124792"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06159"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114865"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10053"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20913"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403075"}],"container-title":["Pediatric Blood &amp; 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