{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:45:42Z","timestamp":1769849142366,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T00:00:00Z","timestamp":1295308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatic veno\u2010occlusive disease (VOD) is a rare and potentially severe complication of chemotherapy. We describe five patients who developed VOD after chemotherapy for Wilms tumor (WT) and evaluate the role of plasminogen activator inhibitor\u20101 (PAI\u20101) and defibrotide for diagnosis and therapy of VOD, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Thirty\u2010five patients treated from 2002 to 2009 for WT were eligible. Diagnosis of VOD was according McDonald's criteria that required two of the following: jaundice, hepatomegaly and\/or right upper quadrant pain, weight gain with or without ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VOD occurred in 5 of 35 patients (14%) after 21\u2013105 days from starting chemotherapy. Two patients developed multiorgan failure (MOF). PAI\u20101 was high in four patients who were tested. Three patients were treated with defibrotide and no side effects were reported while two patients received supportive measures only. Four patients recovered and three of them received defibrotide. They are all alive and well after a median follow\u2010up of 35 months. One of two patients not treated with defibrotide died of MOF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PAI\u20101 levels were abnormal in WT\u2010VOD. Defibrotide was a safe, well\u2010tolerated, and potentially efficacious therapy in this group of patients. Further prospective study is needed in WT\u2010VOD to confirm these data. Pediatr Blood Cancer 2011; 57: 258\u2013261. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22841","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T17:47:21Z","timestamp":1295372841000},"page":"258-261","source":"Crossref","is-referenced-by-count":26,"title":["Veno\u2010occlusive disease in pediatric patients affected by Wilms tumor"],"prefix":"10.1002","volume":"57","author":[{"given":"Simone","family":"Cesaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Spiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Peruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Saggiorato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1396","article-title":"A prospective survey on incidence, risk factors and therapy of hepatic veno\u2010occlusive disease in children after hematopoietic stem cell transplantation","volume":"90","author":"Cesaro S","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00097-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<245::AID-MPO2>3.0.CO;2-M"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(94)90427-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22202"},{"key":"e_1_2_6_7_2","first-page":"3599","article-title":"Incidence and outcome of hepatic venoocclusive disease after blood or marrow transplantation: A prospective cohort study of the European Group for Blood and Marrow Transplantation. 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