{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:05:57Z","timestamp":1761059157649},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T00:00:00Z","timestamp":1292371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperimmunoglobulinemia is documented in patients with Gaucher disease of all ages. We investigated the frequency of hyperimmunoglobulinemia in 12 pediatric patients with type I and III Gaucher disease and the effects of enzyme replacement therapy on these abnormalities. The incidence of hyperimmunoglobulinemia was 77%, 66%, and 60% at the diagnosis, before and after ERT, respectively. Immunoglobulin G abnormalities were the most commonly seen isotype abnormality. After enzyme replacement therapy normalization of IgA and IgM levels were recorded but decline in IgG levels was less likely to occur. This study indicated the higher frequency of hyperimmunoglobulinemia in pediatric Gaucher patients. Pediatr Blood Cancer 2011;56:664\u2013666. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22863","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T17:51:15Z","timestamp":1292435475000},"page":"664-666","source":"Crossref","is-referenced-by-count":10,"title":["Immunoglobulin abnormalities and effects of enzyme replacement therapy in children with Gaucher disease"],"prefix":"10.1002","volume":"56","author":[{"given":"Zeynep","family":"Ar\u0131kan\u2010Ayy\u0131ld\u0131z","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Yuce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Uslu\u2010K\u0131z\u0131lkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Gurakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood.V31.5.633.633","article-title":"Immunoglobulin abnormalities in Gaucher disease. Report of 16 cases","volume":"31","author":"Pratt PW","year":"1968","journal-title":"Blood"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830290403"},{"key":"e_1_2_5_4_2","first-page":"388","article-title":"Gaucher's disease: a disease with chronic stimulation of the immune system","volume":"106","author":"Shoenfeld Y","year":"1982","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.10.007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood.V104.11.2391.2391","article-title":"High prevelence of B\u2010cell clonalityin patients with Gaucher disease","volume":"104","author":"Hughes D","year":"2004","journal-title":"Blood"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31806451d3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199211000-00002"},{"key":"e_1_2_5_9_2","first-page":"479","article-title":"Enzyme replacement therapy decrease hypergammoglobulinemia in Gaucher's disease","volume":"83","author":"Deibener J","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831236"},{"key":"e_1_2_5_11_2","first-page":"205","article-title":"Cytokines in Gaucher disease","volume":"10","author":"Barak V","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1997.0137"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(96)00056-7"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22863","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:28:05Z","timestamp":1700490485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,15]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/pbc.22863"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22863","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,15]]}}}