{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:18:33Z","timestamp":1789928313671,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T00:00:00Z","timestamp":1299024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Modern WT management consist of ample chemotherapy, nephron\u2010sparing surgery, and, when indicated, radiotherapy. Survivors may develop renal failure or secondary tumors due to anticancer treatment. We analyzed long\u2010term outcome (follow\u2010up &gt;5 years) after bilateral Wilms tumor (BWT) treatment with respect to survival, renal function, and secondary malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 41 patients (23 females, 28 synchronous tumors) diagnosed with BWT between 1967 and 2007, 25 (18 females, 14 synchronous) with a follow\u2010up &gt;5 years could be included. Of this subgroup, median age at diagnosis was 1.64 years (range 0.27\u20135.35), and at maximum follow\u2010up 14.99 years (range 5.40\u201333.99). Data were retrospectively collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One patient (4%) died 17.75 years after diagnosis, five (20%) had renal transplants: 3\/5 after bilateral nephrectomy for Denys\u2013Drash syndrome (DDS), and 2\/5 for ESRD after an interval of 7 and 18 years, respectively. All transplanted patients remained in CR. Another three patients developed mild renal insufficiency (creatinine levels 1.3, 1.8, and 2.8\u2009mg\/100\u2009ml, respectively; N\u2009=\u20090.5\u20131.2), combined with hypertension in 1; neither of them was transplanted. Sixteen (64%) had normal renal function and were in CR. Long\u2010term renal function appeared significantly better after bilateral nephron sparing surgery (NSS) then after other surgical procedures (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Seven secondary tumors were found in five (20%) patients, one of whom had a DDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term 10\u2010year overall survival was 78%. There was significant morbidity (13\/25, 52%), in terms of renal failure (8\/25, 32%) including renal transplantation (5\/25, 20%), and secondary tumors (5\/25). These findings necessitate long\u2010term follow\u2010up beyond childhood. Future work should be directed at reducing the harmful effects of treatment, including the increased use of NSS. Pediatr Blood Cancer 2011;56:1110\u20131113. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.22881","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T04:55:09Z","timestamp":1299128109000},"page":"1110-1113","source":"Crossref","is-referenced-by-count":33,"title":["Long\u2010term outcome of bilateral Wilms tumors (BWT)"],"prefix":"10.1002","volume":"56","author":[{"given":"Daniel C.","family":"Aronson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Slaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Heinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"de Kraker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Heij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000176800.00994.3a"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199602)26:2<75::AID-MPO1>3.0.CO;2-R"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.365"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-10-815"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199276822"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.05.013"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.183"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23406"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62588-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.07.009"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68033-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90077-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.6.1506"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<239::AID-MPO1>3.0.CO;2-N"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.8.592"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.8.1851"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23333"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22881","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22881","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:51:56Z","timestamp":1697601116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,2]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/pbc.22881"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22881","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,2]]}}}