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Though cutaneous vasculitis is known to occur in WAS, presentation in early infancy and as AHEI is extremely uncommon. Hyperostosis is not a well\u2010recognized association in WAS; only three patients with this association have been previously reported. In our patient these two unusual manifestations preceded the onset of recurrent infections. Recognition of this rare presentation led us to an early diagnosis of WAS, associated with p.Glu31Lys mutation in the WAS protein. Pediatr Blood Cancer 2011;56:1130\u20131132. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22888","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T10:09:42Z","timestamp":1298714982000},"page":"1130-1132","source":"Crossref","is-referenced-by-count":3,"title":["Wiskott\u2013Aldrich syndrome presenting with early onset recurrent acute hemorrhagic edema and hyperostosis"],"prefix":"10.1002","volume":"56","author":[{"given":"Shanmuganathan","family":"Chandrakasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Delaunay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Proust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana W.","family":"Minz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,23]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.5.e622"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82002-5"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200307000-00012"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100583"},{"key":"e_1_2_4_6_2","first-page":"654","article-title":"Cutaneous T cell lymphoma and leukocytoclastic vasculitis in a long\u2010term survivor of Wiskott\u2013Aldrich syndrome","volume":"55","author":"Watson RD","year":"1985","journal-title":"Ann Allergy"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80002-4"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.10.818"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441979"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2007.02.007"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70002-J"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.005"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.007"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22760"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.126.4.677"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199704000-00013"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200112)31:12<3413::AID-IMMU3413>3.0.CO;2-P"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22888","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:53:33Z","timestamp":1697601213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,23]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/pbc.22888"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22888","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,23]]}}}