{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:24:48Z","timestamp":1759991088476},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T00:00:00Z","timestamp":1288915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 3\u2010year\u2010old male presented with <jats:italic>Chlamydia pneumoniae<\/jats:italic> infection\u2010related hemophagocytic lymphohistiocytosis (HLH). The patient developed an episode of HLH with severe skin eruption following <jats:italic>C. pneumoniae<\/jats:italic> pneumonia. Symptoms responded to steroid\/cyclosporine A therapy, but the patient slowly lost consciousness and developed systemic flaccid paralysis. He was diagnosed with encephalitis\/myelitis by brain and spinal MRI. Neurological symptoms and signs gradually resolved. We thought that the immune response to <jats:italic>C. pneumoniae<\/jats:italic> infection triggered the development of HLH, associated with unusual neurological complications. This report describes a novel case of <jats:italic>C. pneumoniae<\/jats:italic>\u2010associated HLH and with poliomyelitis like flaccid paralysis. Pediatr Blood Cancer 2011;56:853\u2013855. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22889","type":"journal-article","created":{"date-parts":[[2010,11,7]],"date-time":"2010-11-07T13:41:56Z","timestamp":1289137316000},"page":"853-855","source":"Crossref","is-referenced-by-count":12,"title":["<i>Chlamydia pneumoniae<\/i> infection\u2010related hemophagocytic lymphohistiocytosis and acute encephalitis and poliomyelitis\u2010like flaccid paralysis"],"prefix":"10.1002","volume":"56","author":[{"given":"Kanae","family":"Yagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Kano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Imashuku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,5]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2009.10.002"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20274"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20511"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-0065-0"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.02.050"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309008494"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2000.00090.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1778"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/313633"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202203260818"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.6.511"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408113310618"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-006-0048-1"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken342"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050360"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21838"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02075.x"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.6074"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22889","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:05:50Z","timestamp":1697601950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/pbc.22889"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22889","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,5]]}}}