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This report examines two adolescents with sickle cell disease (SCD) who died during worsening symptoms consistent with asthma. Autopsies in both individuals demonstrated pulmonary airway smooth muscle hyperplasia, basement membrane thickening, and eosinophilia, consistent with bronchial asthma. Individuals with SCD and asthma warrant ongoing education, treatment, and surveillance for life\u2010threatening complications of asthma. Pediatr Blood Cancer 2011;56:454\u2013457. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22891","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T13:50:56Z","timestamp":1290952256000},"page":"454-457","source":"Crossref","is-referenced-by-count":11,"title":["Death due to asthma in two adolescents with sickle cell disease"],"prefix":"10.1002","volume":"56","author":[{"given":"Joshua J.","family":"Field","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Strunk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances V.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"DeBaun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-011072"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029165"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13090"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11213"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1787"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3336"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460418"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212968.98501.2b"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31410-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.066407"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9708092"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202203260801"},{"key":"e_1_2_6_14_2","unstructured":"Expert report panel 3: Guidelines for the diagnosis and management of asthma. 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