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We describe a patient with dysmorphic features who was diagnosed with pre\u2010B acute lymphoblastic leukemia, and developed cystinuria and pancreatitis during treatment. Duplication 22q11.2 has not been previously described in association with hematologic abnormalities. Chromosomal microarray technology was used to diagnose duplication 22q11.2 syndrome. In this era of advanced genomics, this technology has become an important method for helping to determine the molecular basis of diseases, best treatments and ultimately patient outcomes. Pediatr Blood Cancer 2011;56:470\u2013473. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.22909","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T13:51:34Z","timestamp":1290952294000},"page":"470-473","source":"Crossref","is-referenced-by-count":8,"title":["B\u2010Acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis"],"prefix":"10.1002","volume":"56","author":[{"given":"Vivian Y.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Quintero\u2010Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin E.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian A.","family":"Martinez\u2010Agosto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte N.","family":"Gomperts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1157"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/429841"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970414)69:4<356::AID-AJMG4>3.0.CO;2-J"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.18"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00031-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00750.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31816b64c2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31289"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00860751"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652408785747997"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid552.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00371.2006"},{"key":"e_1_2_5_14_2","first-page":"32","article-title":"Metabolic factors associated with urinary calculi in children","volume":"4","author":"Naseri M","year":"2010","journal-title":"Iran J Kidney Dis"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.511"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.404"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802158580"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181b87035"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00527-8"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6413"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.04.001"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22909","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.22909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.22909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:44:22Z","timestamp":1696859062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.22909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,28]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/pbc.22909"],"URL":"https:\/\/doi.org\/10.1002\/pbc.22909","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,28]]}}}